Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa05200:Pathways in cancer 173 15.79908675799087 6.389364035641643E-60 CCND1, RASSF5, EPAS1, PRKACG, MMP9, FGF10, MAPK10, CXCR4, SMAD3, ADCY2, ADCY1, PLCB4, COL4A1, FGF2, MDM2, RAC2, PLCG2, APC, CDKN1A, MAP2K2, PRKACB, PDGFB, CASP9, BCL2, GNA11, RB1, ADCY7, ITGB1, CASP8, NFKBIA, VHL, CCNE1, RUNX1, ADCY4, SOS1, PDGFA, BCL2L1, LAMA5, RHOA, TGFA, MAPK9, RELA, EGF, SOS2, CDKN1B, E2F3, MAPK8, COL4A3, CDC42, CBL, PLCB1, PRKCA, CKS1B, MLH1, SUFU, CREBBP, MAP2K1, IL6, FGF1, CTNNB1, HSP90B1, ITGAV, MAPK1, RAC3, MYC, FOS, BMP4, GLI1, RET, FGF13, GNAI3, ADCY3, GLI3, GLI2, HIF1A, PLCG1, MAPK3, JUP, CDK2, TRAF2, AGTR1, EDNRA, BDKRB2, CYCS, ADCY6, RAF1, SMAD2, PIK3CB, PTK2, PIK3CA, CDK4, KRAS, EGFR, RAD51, STAT3, AKT1, ARHGEF11, NRAS, MMP1, IGF1, HDAC2, PIK3CG, PLCB3, CTNNA1, FOXO1, COL4A5, STAT5A, PIK3R1, CDH1, GRB2, PIK3R3, ADCY5, PRKACA, GNAI1, PLCB2, PIAS2, CBLB, FGF7, PRKCB, SPI1, ABL1, RAC1, TP53, IGF1R, TRAF4, SKP2, JUN, LPAR1, EDNRB, VEGFA, PGF, PIK3R2, VEGFC, APC2, KITLG, FN1, VEGFB, CSF1R, HDAC1, AR, RARA, CRKL, HSP90AA1, PIK3CD, CTBP1, HGF, STAT5B, ERBB2, FADD, WNT1, LAMC1, TRAF6, FZD8, CRK, RXRA, FLT3, JAK1, PIK3R5, EP300, PRKCG, GNAQ, NFKB1, LAMA1, KIT, BIRC5, ADCY8, CBLC, SMAD4, ZBTB16, CASP3, FGF4, MSH2, PML 842 393 6910 3.612596930850453 1.5462260966252778E-57 1.5462260966252778E-57 8.257913458073875E-57 KEGG_PATHWAY hsa04151:PI3K-Akt signaling pathway 140 12.785388127853881 8.25988561846273E-43 CCND1, TLR4, FGF10, RPS6, COL3A1, COL4A1, FGF2, ITGB8, MDM2, COL2A1, INS, CDKN1A, INSR, MAP2K2, PDGFB, CASP9, BCL2, ANGPT2, ITGB1, CCNE1, SOS1, PDGFA, BCL2L1, LAMA5, PPP2CA, RELA, EGF, SOS2, IL2RA, TLR2, CDKN1B, NGF, COL4A3, PRKCA, EFNA1, MAP2K1, IL6, FGF1, IL6R, TNXB, YWHAQ, HSP90B1, JAK2, ITGAV, SYK, MAPK1, MYC, EFNA2, YWHAZ, PRKAA1, FGF13, COL1A1, ITGB4, MAPK3, CDK2, ANGPT4, RAF1, CSF1, PRKAA2, PIK3CB, PTK2, PIK3CA, CDK4, MYB, KRAS, EGFR, AKT1, NRAS, IL2RG, IGF1, ITGA5, PPP2CB, COL5A1, PPP2R1A, PIK3CG, YWHAB, SPP1, IRS1, COL4A5, RELN, JAK3, ITGB5, PIK3R1, GRB2, PIK3R3, ANGPT1, FGF7, COL1A2, CREB1, RAC1, TP53, TSC1, IGF1R, TNC, IL4, LPAR1, VEGFA, PGF, PIK3R2, RPS6KB2, VEGFC, FN1, KITLG, VEGFB, CSF1R, CCND2, RPS6KB1, GHR, IL3, YWHAG, EIF4B, HSP90AA1, PIK3CD, HGF, BRCA1, NOS3, GH1, LAMC1, CCND3, THBS1, NR4A1, RXRA, COL6A2, JAK1, PIK3R5, ATF4, ATF2, NFKB1, LAMA1, SGK1, EIF4E, KIT, PRLR, EPOR, TNR, VTN, COL11A1, EFNA4, FGF4, EFNA5 842 345 6910 3.3302351199697062 1.9988923196679806E-40 9.994461598339903E-41 1.0675463196393753E-39 KEGG_PATHWAY hsa04015:Rap1 signaling pathway 103 9.406392694063927 5.476608167542363E-40 RASSF5, FGF10, MAPK12, ADCY1, ADCY2, PLCB4, FGF2, CALM3, PRKD1, RAC2, CTNND1, ID1, INS, INSR, MAP2K2, PDGFB, ANGPT2, ADCY7, ITGB1, ADCY4, PDGFA, TIAM1, RHOA, EGF, DRD2, MAPK14, NGF, CDC42, PRKCA, PLCB1, MAP2K1, EFNA1, FGF1, CTNNB1, RAPGEF1, LCP2, PRKCI, MAPK1, RAC3, EFNA2, RAP1B, GNAI3, FGF13, ADCY3, PLCG1, MAPK3, ANGPT4, ADCY6, RAF1, CSF1, PIK3CB, PIK3CA, ACTG1, KRAS, CNR1, EGFR, NRAS, AKT1, RAPGEF6, IGF1, SRC, ACTB, PIK3CG, PLCB3, PIK3R1, CDH1, PIK3R3, MAPK11, ADCY5, GNAI1, MAPK13, ANGPT1, PLCB2, RGS14, FGF7, PRKCB, LAT, RAC1, IGF1R, LPAR1, VEGFA, PGF, PIK3R2, VEGFC, KITLG, VEGFB, CSF1R, ADORA2A, CRKL, PIK3CD, HGF, THBS1, CRK, PIK3R5, PRKCG, GNAQ, ADCY8, KIT, VASP, EFNA4, FGF4, EFNA5, PRKCZ 842 210 6910 4.025166836330731 1.3253391765452517E-37 4.4177972551508394E-38 7.078225006286355E-37 KEGG_PATHWAY hsa04510:Focal adhesion 101 9.223744292237443 3.571758154447713E-39 CCND1, MAPK10, COL3A1, COL4A1, ITGB8, COL2A1, RAC2, ACTN4, PDGFB, BCL2, SHC2, ITGB1, PAK1, SOS1, PDGFA, LAMA5, SHC3, SHC4, RHOA, MAPK9, EGF, SOS2, MAPK8, COL4A3, CDC42, PRKCA, MAP2K1, CTNNB1, ACTN2, ACTN1, TNXB, RAPGEF1, VAV3, ITGAV, MAPK1, FYN, RAC3, RAP1B, COL1A1, ITGB4, MAPK3, RAF1, PTK2, PXN, PIK3CB, PIK3CA, ACTG1, EGFR, AKT1, IGF1, ITGA5, COL5A1, SRC, ACTB, PIK3CG, SPP1, COL4A5, CAV1, RELN, PPP1CA, ITGB5, PIK3R1, PIK3R3, GRB2, SHC1, VAV2, FLNA, PRKCB, COL1A2, RAC1, IGF1R, JUN, TNC, VAV1, ILK, VEGFA, PGF, PIK3R2, VEGFC, FN1, VEGFB, PPP1CC, CCND2, CRKL, PARVG, PIK3CD, HGF, ERBB2, LAMC1, THBS1, CCND3, CRK, ACTN3, COL6A2, PIK3R5, PRKCG, LAMA1, VASP, TNR, VTN, COL11A1 842 206 6910 4.02364919401333 8.643654733763466E-37 2.1609136834408665E-37 4.6163075961967554E-36 KEGG_PATHWAY hsa05205:Proteoglycans in cancer 99 9.04109589041096 7.744121695907325E-39 CCND1, TLR4, PRKACG, MMP9, RPS6, MAPK12, FGF2, MDM2, PLCG2, CAMK2A, CDKN1A, MAP2K2, HSPG2, PRKACB, SDC2, ITGB1, PAK1, DDX5, SOS1, TIAM1, RHOA, CAMK2G, SOS2, CAMK2B, TLR2, MAPK14, CAMK2D, CDC42, CBL, PRKCA, MAP2K1, ITPR1, ERBB4, CTNNB1, ITGAV, PTPN11, MAPK1, MYC, HIF1A, PLCG1, MAPK3, RAF1, PXN, PTK2, PIK3CB, PIK3CA, ACTG1, PDCD4, KRAS, EGFR, NRAS, AKT1, STAT3, IGF1, ITGA5, SRC, ACTB, PIK3CG, CAV1, PPP1CA, ITGB5, PIK3R1, EZR, PTPN6, PIK3R3, GRB2, MAPK11, PRKACA, MAPK13, CBLB, FLNA, PRKCB, IGF2, RAC1, TP53, IGF1R, VEGFA, PLAU, PIK3R2, RPS6KB2, HBEGF, FN1, PPP1CC, RPS6KB1, TNF, EIF4B, PIK3CD, HGF, ERBB2, WNT1, THBS1, FZD8, PIK3R5, PRKCG, GAB1, ESR1, CBLC, VTN, CASP3 842 200 6910 4.06229216152019 1.8740774504095725E-36 3.748154900819145E-37 1.000886573638042E-35 KEGG_PATHWAY hsa04915:Estrogen signaling pathway 68 6.210045662100456 9.961324742792305E-39 SRC, PRKACG, PIK3CG, MMP9, PLCB3, ADCY1, ADCY2, PLCB4, CALM3, HSPA8, PIK3R1, GRB2, PIK3R3, ADCY5, PRKACA, GNAI1, MAP2K2, PRKACB, SHC1, SHC2, ADCY7, PLCB2, ADCY4, SOS1, CREB1, GABBR2, JUN, ESR2, SHC3, SHC4, GABBR1, SOS2, GRM1, PIK3R2, HBEGF, PLCB1, MAP2K1, KCNJ9, ITPR1, HSP90AA1, KCNJ6, PIK3CD, HSP90B1, NOS3, MAPK1, OPRM1, FOS, GNAI3, ADCY3, KCNJ3, ATF4, PIK3R5, ATF2, GNAQ, MAPK3, PRKCD, ADCY6, ADCY8, RAF1, ESR1, PIK3CB, HSPA1A, PIK3CA, KRAS, SP1, EGFR, NRAS, AKT1 842 99 6910 5.636891480121884 2.4106405877557377E-36 4.01773431292623E-37 1.2874482842874676E-35 KEGG_PATHWAY hsa04012:ErbB signaling pathway 63 5.7534246575342465 5.362294261429681E-38 SRC, PIK3CG, MAPK10, STAT5A, PIK3R1, AREG, GRB2, PIK3R3, PLCG2, CAMK2A, CDKN1A, MAP2K2, SHC1, SHC2, PAK1, CBLB, ABL1, PRKCB, SOS1, JUN, SHC3, SHC4, TGFA, MAPK9, CAMK2G, MAP2K4, EGF, SOS2, CAMK2B, PIK3R2, RPS6KB2, CAMK2D, CDKN1B, MAPK8, HBEGF, RPS6KB1, CBL, PRKCA, MAP2K1, ERBB4, CRKL, PIK3CD, STAT5B, ERBB2, MAPK1, BTC, MYC, CRK, PIK3R5, PRKCG, PLCG1, MAPK3, GAB1, RAF1, CBLC, PTK2, PIK3CB, PIK3CA, KRAS, NCK1, EGFR, NRAS, AKT1 842 87 6910 5.942747153739045 1.297675211265983E-35 1.8538217303799752E-36 6.930480357763114E-35 KEGG_PATHWAY hsa04917:Prolactin signaling pathway 54 4.931506849315069 2.62192399725594E-34 CCND1, SRC, PIK3CG, MAPK12, MAPK10, STAT5A, SOCS5, SOCS1, PIK3R1, SLC2A2, SOCS7, SOCS4, PIK3R3, GRB2, MAPK11, INS, MAP2K2, MAPK13, SHC1, SHC2, SOS1, CISH, ESR2, SHC3, SHC4, RELA, MAPK9, SOS2, MAPK14, PIK3R2, SOCS2, SOCS3, MAPK8, IRF1, CCND2, MAP2K1, PIK3CD, JAK2, STAT5B, MAPK1, FOS, PIK3R5, MAPK3, NFKB1, PRLR, RAF1, ESR1, PIK3CB, PIK3CA, LHCGR, KRAS, NRAS, AKT1, STAT3 842 71 6910 6.24167809708608 6.345056073359374E-32 7.931320091699218E-33 3.388697426255247E-31 KEGG_PATHWAY hsa05161:Hepatitis B 76 6.940639269406393 7.874740103532911E-32 DDB1, CCND1, SRC, PTK2B, PIK3CG, TLR4, MMP9, MAPK10, YWHAB, STAT6, STAT5A, PIK3R1, GRB2, PIK3R3, CDKN1A, MAP2K2, HSPG2, CASP9, BCL2, RB1, CASP8, NFKBIA, CCNE1, PRKCB, CREB1, TP53, JUN, TIRAP, STAT2, RELA, MAPK9, MAP2K4, PIK3R2, TLR2, E2F3, CDKN1B, MAPK8, MYD88, PRKCA, TNF, MAP2K1, CREBBP, IKBKE, IL6, YWHAQ, PIK3CD, STAT5B, FADD, MAPK1, MYC, FOS, PCNA, YWHAZ, JAK1, PIK3R5, EP300, ATF4, CCNA1, PRKCG, ATF2, MAPK3, NFKB1, CDK2, BIRC5, CYCS, RAF1, PIK3CB, SMAD4, CDK4, PIK3CA, STAT4, CASP3, KRAS, STAT3, NRAS, AKT1 842 145 6910 4.301416987468261 1.9056871050549646E-29 2.1174301167277384E-30 1.01776830866185E-28 KEGG_PATHWAY hsa05169:Epstein-Barr virus infection 88 8.036529680365296 1.1039915656464462E-31 PSMD2, HDAC2, SNW1, PIK3CG, PRKACG, MAPK12, MAPK10, YWHAB, JAK3, PIK3R1, RBPJL, HSPA8, PIK3R3, MDM2, EIF2AK1, PLCG2, EIF2AK4, MAPK11, RAN, CDKN1A, PRKACA, PRKACB, MAPK13, BCL2, RB1, POLR2H, NFKBIA, NEDD4, SPI1, POLR2D, USP7, POLR2A, TP53, JUN, SKP2, MAPK9, RELA, MAP2K4, PIK3R2, MAPK14, PSMC1, CDKN1B, MAPK8, CSNK2A2, CSNK2B, RBPJ, CREBBP, CDK1, CSNK2A1, YWHAG, HDAC1, POLR2B, YWHAQ, PIK3CD, VIM, HDAC4, IRAK1, SYK, IL10, PSMD4, MYC, FGR, TRAF6, LYN, YWHAZ, IFNG, JAK1, PIK3R5, EP300, NFKBIB, TBP, EIF2AK2, CCNA1, PLCG1, ATF2, TBPL1, NFKB1, CDK2, TRAF2, PIK3CB, TYK2, EIF2AK3, PIK3CA, HSPA1A, XPO1, NUP214, STAT3, AKT1 842 190 6910 3.8009751218902363 2.6716595888644E-29 2.6716595888643998E-30 1.4268504277885156E-28 KEGG_PATHWAY hsa04664:Fc epsilon RI signaling pathway 50 4.5662100456621 1.4030093557225479E-30 PIK3CG, MAPK12, MAPK10, BTK, PIK3R1, PIK3R3, GRB2, RAC2, PLCG2, MAPK11, MAP2K2, MAPK13, VAV2, PRKCB, LAT, SOS1, PLA2G4A, RAC1, INPP5D, IL4, VAV1, MAPK9, MAP2K4, SOS2, MAPK14, PIK3R2, MAPK8, PRKCA, TNF, IL3, MAP2K1, LCP2, VAV3, PIK3CD, SYK, MAPK1, FYN, RAC3, LYN, GAB2, PIK3R5, PLCG1, MAPK3, RAF1, PIK3CB, PIK3CA, PLA2G4B, KRAS, NRAS, AKT1 842 68 6910 6.034302081877882 3.395282640848566E-28 3.0866205825896054E-29 1.8133150303841285E-27 KEGG_PATHWAY hsa04068:FoxO signaling pathway 71 6.4840182648401825 4.1572045862441544E-30 CCNB2, CCND1, IGF1, PIK3CG, MAPK12, MAPK10, IRS1, SMAD3, FOXO1, PLK1, PIK3R1, GRB2, PIK3R3, MDM2, PRKAG1, MAPK11, PRKAB2, IRS4, INS, CDKN1A, INSR, GABARAP, MAP2K2, MAPK13, PRMT1, SOS1, USP7, PRKAG2, IGF1R, CCNB1, SKP2, SOD2, MAPK9, EGF, SOS2, GRM1, PIK3R2, MAPK14, CDKN1B, MAPK8, PRKAG3, CCND2, MAP2K1, CREBBP, IL6, ATM, PIK3CD, IL10, MAPK1, PRKAB1, SIRT1, PRKAA1, PIK3R5, EP300, MAPK3, CDK2, SGK1, IRS2, RAF1, SLC2A4, SMAD2, HOMER3, PIK3CB, PRKAA2, SMAD4, PIK3CA, KRAS, EGFR, STAT3, NRAS, AKT1 842 134 6910 4.348300067359166 1.0060435098710854E-27 8.383695915592378E-29 5.372965996179071E-27 KEGG_PATHWAY hsa05220:Chronic myeloid leukemia 51 4.657534246575342 6.003176674652244E-30 CCND1, HDAC2, CBL, PIK3CG, MAP2K1, STAT5A, HDAC1, PIK3R1, CRKL, PIK3CD, CTBP1, GRB2, PIK3R3, MDM2, STAT5B, PTPN11, MAPK1, CDKN1A, MYC, MAP2K2, CRK, SHC1, RB1, SHC2, GAB2, PIK3R5, CBLB, NFKBIA, RUNX1, MAPK3, ABL1, NFKB1, SOS1, TP53, RAF1, BCL2L1, CBLC, PIK3CB, SMAD4, SHC3, SHC4, CDK4, PIK3CA, RELA, SOS2, KRAS, PIK3R2, CDKN1B, NRAS, E2F3, AKT1 842 72 6910 5.813044338875693 1.452768755265843E-27 1.1175144271275717E-28 7.758786817634747E-27 KEGG_PATHWAY hsa05214:Glioma 47 4.292237442922374 3.3032182277289547E-28 CCND1, IGF1, PRKCA, PIK3CG, MAP2K1, CALM3, PIK3R1, PIK3CD, GRB2, PIK3R3, MDM2, PLCG2, CAMK2A, MAPK1, CDKN1A, MAP2K2, PDGFB, SHC1, RB1, SHC2, PIK3R5, PRKCG, PLCG1, MAPK3, PRKCB, PDGFA, SOS1, TP53, IGF1R, RAF1, PIK3CB, SHC3, PIK3CA, CDK4, SHC4, TGFA, CAMK2G, EGF, SOS2, KRAS, CAMK2B, PIK3R2, EGFR, E2F3, CAMK2D, AKT1, NRAS 842 65 6910 5.934039831902064 7.99378811110407E-26 5.709848650788621E-27 4.26923401226716E-25 KEGG_PATHWAY hsa04540:Gap junction 55 5.0228310502283104 3.7320917469141816E-28 TUBB, TUBA1A, SRC, PRKACG, PLCB3, ADCY1, TUBB4B, ADCY2, PLCB4, GRB2, TUBA4A, ADCY5, PRKACA, MAP2K2, GNAI1, DRD1, PDGFB, PRKACB, GNA11, ADCY7, PLCB2, ADCY4, TUBA1B, PRKCB, PDGFA, SOS1, LPAR1, SOS2, EGF, DRD2, GRM1, PRKCA, PLCB1, MAP2K1, CDK1, ITPR1, ADRB1, GJA1, MAPK1, TJP1, GNAI3, ADCY3, HTR2A, PRKCG, GNAQ, MAPK3, ADCY6, ADCY8, RAF1, TUBA3C, MAP3K2, TUBB2A, KRAS, EGFR, NRAS 842 88 6910 5.129156769596199 9.03166202753232E-26 6.021108018354879E-27 4.823530243650309E-25 KEGG_PATHWAY hsa05203:Viral carcinogenesis 87 7.9452054794520555 6.323460942262213E-28 DDB1, CCND1, SRC, HDAC2, SNW1, CDC20, PRKACG, PIK3CG, YWHAB, STAT5A, JAK3, RBPJL, PIK3R1, GRB2, PIK3R3, MDM2, CDKN1A, ACTN4, PRKACA, CCR3, C3, PRKACB, RB1, CASP8, NFKBIA, KAT2A, CCNE1, USP7, KAT2B, RAC1, CREB1, TP53, JUN, SKP2, RHOA, RELA, PIK3R2, PSMC1, CDKN1B, DLG1, CDC42, CCND2, HDAC6, HDAC3, RBPJ, CREBBP, CDK1, YWHAG, ACTN2, ACTN1, HDAC1, YWHAQ, PIK3CD, STAT5B, HDAC4, SYK, HIST1H2BJ, MAPK1, SRF, CCND3, HIST1H4A, LYN, YWHAZ, JAK1, ACTN3, PIK3R5, EP300, ATF4, TBP, CCNA1, EIF2AK2, ATF2, MAPK3, TBPL1, NFKB1, CDK2, TRAF2, CCR5, PXN, PIK3CB, CDK4, PIK3CA, IL6ST, CASP3, KRAS, STAT3, NRAS 842 205 6910 3.4828225479404438 1.5302775480274555E-25 9.564234675171597E-27 8.172737212251775E-25 KEGG_PATHWAY hsa04062:Chemokine signaling pathway 82 7.488584474885844 1.120118145496483E-27 SRC, PTK2B, PPBP, PRKACG, PIK3CG, PLCB3, CXCR4, ADCY1, ADCY2, PLCB4, JAK3, PIK3R1, GRB2, PIK3R3, RAC2, ADCY5, CCR10, PRKACA, CCR3, GNAI1, PRKACB, SHC1, WASL, SHC2, ADCY7, PLCB2, PAK1, NFKBIA, VAV2, ADCY4, SOS1, RAC1, CCR2, TIAM1, ARRB2, STAT2, VAV1, SHC3, RHOA, SHC4, RELA, SOS2, PIK3R2, ARRB1, CDC42, PLCB1, MAP2K1, CXCR2, CRKL, VAV3, PIK3CD, JAK2, STAT5B, MAPK1, HCK, FGR, CRK, LYN, RAP1B, GNAI3, ADCY3, WAS, PIK3R5, NFKBIB, MAPK3, NFKB1, PRKCD, ADCY6, ADCY8, RAF1, CCR5, PXN, PTK2, PIK3CB, PIK3CA, CCR1, KRAS, STAT3, NRAS, AKT1, PRKCZ, CCR9 842 186 6910 3.6179858503818356 2.710685912101489E-25 1.5945211247655816E-26 1.447693175209613E-24 KEGG_PATHWAY hsa04660:T cell receptor signaling pathway 59 5.3881278538812785 2.218180181716316E-27 PPP3CA, PIK3CG, MAPK12, PIK3R1, PTPN6, GRB2, PIK3R3, MAPK11, MAP2K2, PPP3R1, MAPK13, PAK1, PTPRC, NFKBIA, CBLB, VAV2, GRAP2, LAT, SOS1, JUN, IL4, VAV1, RHOA, RELA, SOS2, MAPK14, PIK3R2, DLG1, LCK, CDC42, CD4, CBL, TNF, MAP2K1, PPP3CB, TEC, LCP2, VAV3, PIK3CD, IL10, MAPK1, FYN, FOS, IFNG, PIK3R5, NFKBIB, PPP3CC, PLCG1, MAPK3, NFKB1, RAF1, CBLC, PIK3CB, CDK4, PIK3CA, KRAS, NCK1, NRAS, AKT1 842 103 6910 4.700897078154187 5.367996039753485E-25 2.9822200220852695E-26 2.866880001334656E-24 KEGG_PATHWAY hsa04722:Neurotrophin signaling pathway 64 5.844748858447488 2.427601076594401E-27 PIK3CG, MAPK12, MAPK10, IRS1, CALM3, PIK3R1, GRB2, PIK3R3, PLCG2, CAMK2A, MAPK11, MAP2K2, SHC1, MAPK13, BCL2, SHC2, NFKBIA, ABL1, SOS1, RAC1, TP53, JUN, SHC3, RHOA, SHC4, MAPK9, CAMK2G, RELA, SOS2, PIK3R2, CAMK2B, MAPK14, CAMK2D, MAPK8, NGF, CDC42, MAP2K1, RAPGEF1, CRKL, MAGED1, PIK3CD, IRAK1, PTPN11, MAPK1, TRAF6, CRK, RAP1B, PIK3R5, ATF4, RPS6KA3, NFKBIB, RIPK2, PLCG1, MAPK3, NFKB1, PRKCD, GAB1, RAF1, PIK3CB, PIK3CA, KRAS, RPS6KA5, NRAS, AKT1 842 120 6910 4.376880443388757 5.87479460535845E-25 3.091997160714974E-26 3.137545378447097E-24 KEGG_PATHWAY hsa04912:GnRH signaling pathway 55 5.0228310502283104 4.039482370894948E-27 SRC, PTK2B, PRKACG, MAPK12, PLCB3, MAPK10, ADCY1, ADCY2, PLCB4, CALM3, GRB2, CAMK2A, MAPK11, ADCY5, PRKACA, MAP2K2, PRKACB, MAPK13, GNA11, ADCY7, PLCB2, CACNA1S, ADCY4, PRKCB, SOS1, PLA2G4A, JUN, CAMK2G, MAPK9, MAP2K4, SOS2, CAMK2B, MAPK14, CAMK2D, MAPK8, HBEGF, CDC42, PRKCA, PLCB1, MAP2K1, ITPR1, MAPK1, ADCY3, ATF4, GNAQ, MAPK3, PRKCD, ADCY6, ADCY8, RAF1, MAP3K2, PLA2G4B, KRAS, EGFR, NRAS 842 91 6910 4.960063689279841 9.775547337565775E-25 4.887773668782887E-26 5.220816289099679E-24 KEGG_PATHWAY hsa04914:Progesterone-mediated oocyte maturation 53 4.840182648401827 2.2967866200401067E-26 CCNB2, IGF1, PRKACG, PIK3CG, MAPK12, MAPK10, ADCY1, ADCY2, PLK1, PIK3R1, PIK3R3, MAPK11, ADCY5, CDC27, INS, PRKACA, GNAI1, PRKACB, MAPK13, ANAPC11, ADCY7, ADCY4, CCNB1, IGF1R, MAPK9, MAPK14, PIK3R2, MAPK8, ANAPC7, MAD2L1, ANAPC2, MAP2K1, CDK1, CDC23, HSP90AA1, PIK3CD, MAPK1, MAD2L2, GNAI3, ADCY3, PIK3R5, RPS6KA3, CCNA1, MAPK3, CDK2, ADCY6, ADCY8, RAF1, CPEB1, PIK3CB, PIK3CA, KRAS, AKT1 842 87 6910 4.999453954732847 5.558223620497058E-24 2.646773152617647E-25 2.968474645387536E-23 KEGG_PATHWAY hsa04114:Oocyte meiosis 59 5.3881278538812785 1.1977797844576323E-25 IGF1, PPP2CB, CDC20, PPP2R1A, PRKACG, PPP3CA, YWHAB, ADCY2, ADCY1, PPP1CA, CALM3, PLK1, ESPL1, CAMK2A, ADCY5, CDC27, INS, PRKACA, SMC3, PRKACB, PPP3R1, ANAPC11, ADCY7, CCNE1, ADCY4, IGF1R, PPP2CA, SMC1A, CAMK2G, CAMK2B, CAMK2D, ANAPC7, MAD2L1, ANAPC2, PPP1CC, PTTG1, BTRC, MAP2K1, PTTG2, CDK1, ITPR1, YWHAG, PPP3CB, CDC23, AR, YWHAQ, SKP1, MAPK1, MAD2L2, YWHAZ, SMC1B, ADCY3, RPS6KA3, PPP3CC, MAPK3, CDK2, ADCY6, ADCY8, CPEB1 842 109 6910 4.442132101375057 2.89862707838747E-23 1.3175577629033955E-24 1.5480667162969372E-22 KEGG_PATHWAY hsa05166:HTLV-I infection 95 8.67579908675799 3.064828179230277E-25 CCND1, IL2RG, CDC20, PPP3CA, PIK3CG, PRKACG, SMAD3, ADCY1, STAT5A, ADCY2, NRP1, EGR1, JAK3, PIK3R1, PIK3R3, APC, ADCY5, CDC27, RAN, CDKN1A, PRKACA, PRKACB, PDGFB, PPP3R1, RB1, ANAPC11, ADCY7, NFKBIA, KAT2A, ADCY4, SPI1, PDGFA, KAT2B, CREB1, TP53, JUN, BCL2L1, RELA, MAP2K4, IL2RA, PIK3R2, E2F3, DLG1, ANAPC7, APC2, MAD2L1, ANAPC2, LCK, CCND2, PTTG1, TNF, CREBBP, POLD2, PTTG2, IL6, CTNNB1, PPP3CB, CDC23, ATM, PIK3CD, STAT5B, WNT1, MYC, SRF, FOS, CCND3, PCNA, FZD8, ADCY3, JAK1, PIK3R5, ATF4, EP300, PPP3CC, TBP, ETS1, ATF2, CHEK2, TBPL1, NFKB1, NFYB, ADCY6, ADCY8, SMAD2, ATR, PIK3CB, SMAD4, XPO1, CDK4, PIK3CA, MYB, KRAS, GPS2, NRAS, AKT1 842 256 6910 3.0454368319477436 7.416884193737271E-23 3.2247322581466395E-24 3.9611275436441967E-22 KEGG_PATHWAY hsa04014:Ras signaling pathway 88 8.036529680365296 4.552533157544234E-25 RASSF5, IGF1, PRKACG, PIK3CG, FGF10, MAPK10, FGF2, CALM3, PIK3R1, GRB2, PIK3R3, RAC2, PLCG2, INS, PRKACA, INSR, MAP2K2, PRKACB, PDGFB, SHC1, ANGPT1, RASA1, SHC2, ANGPT2, PAK1, FGF7, ABL1, PRKCB, LAT, SOS1, PDGFA, PLA2G4A, RAC1, IGF1R, BCL2L1, TIAM1, SHC3, RHOA, SHC4, MAPK9, RELA, EGF, SOS2, PGF, VEGFA, PIK3R2, MAPK8, NGF, VEGFC, PLA2G2A, KITLG, VEGFB, CDC42, CSF1R, PRKCA, EFNA1, MAP2K1, FGF1, PIK3CD, HGF, PTPN11, MAPK1, RAC3, EFNA2, RAP1B, FGF13, GAB2, PIK3R5, ETS1, PRKCG, PLCG1, MAPK3, NFKB1, ANGPT4, KIT, GAB1, RAF1, CSF1, PIK3CB, PIK3CA, EFNA4, KRAS, FGF4, PLA2G4B, EGFR, EFNA5, NRAS, AKT1 842 226 6910 3.195510058226305 1.1017130241257047E-22 4.590470933857103E-24 5.8839071651419395E-22 KEGG_PATHWAY hsa04750:Inflammatory mediator regulation of TRP channels 55 5.0228310502283104 6.178234653943943E-25 IGF1, SRC, PRKACG, PIK3CG, PLCB3, MAPK12, MAPK10, ADCY1, ADCY2, PLCB4, PPP1CA, PRKCE, CALM3, PIK3R1, PIK3R3, PLCG2, MAPK11, CAMK2A, ADCY5, PRKACA, PRKACB, MAPK13, ADCY7, PLCB2, IL1RAP, ADCY4, PRKCB, PLA2G4A, CAMK2G, MAPK9, CAMK2B, MAPK14, PIK3R2, CAMK2D, MAPK8, NGF, PPP1CC, PRKCA, PLCB1, ITPR1, PIK3CD, TRPV4, ADCY3, PIK3R5, HTR2A, PRKCG, PLCG1, GNAQ, PRKCD, BDKRB2, ADCY6, ADCY8, PIK3CB, PIK3CA, PLA2G4B 842 98 6910 4.605773425759852 1.495132786254434E-22 5.980531145017736E-24 7.98503995254334E-22 KEGG_PATHWAY hsa04910:Insulin signaling pathway 66 6.027397260273973 1.0262396777017088E-24 PRKACG, PIK3CG, RPS6, MAPK10, IRS1, FOXO1, SOCS1, PPP1CA, CALM3, PIK3R1, SOCS4, GRB2, PIK3R3, PRKAG1, PRKAB2, IRS4, INS, PRKACA, INSR, MAP2K2, PRKACB, SHC1, SHC2, CBLB, SOS1, PRKAG2, TSC1, SHC3, SHC4, MAPK9, SOS2, PIK3R2, RPS6KB2, SOCS2, SOCS3, MAPK8, PRKAG3, PPP1CC, RPS6KB1, CBL, MAP2K1, PRKAR1A, RAPGEF1, PTPRF, CRKL, PRKCI, PIK3CD, MAPK1, CRK, PRKAB1, PRKAA1, PIK3R5, MAPK3, IRS2, EIF4E, RAF1, SLC2A4, ACACA, CBLC, PIK3CB, PRKAA2, PIK3CA, KRAS, NRAS, AKT1, PRKCZ 842 138 6910 3.92491996282144 2.483500020038135E-22 9.551923153992829E-24 1.3263602446861186E-21 KEGG_PATHWAY hsa04921:Oxytocin signaling pathway 71 6.4840182648401825 1.4488827547791738E-24 CCND1, SRC, PPP3CA, PRKACG, ACTB, PIK3CG, PLCB3, ADCY1, ADCY2, PLCB4, PPP1CA, CALM3, PIK3R1, PIK3R3, PRKAG1, CAMK2A, PRKAB2, ADCY5, CDKN1A, PRKACA, GNAI1, MAP2K2, PRKACB, PPP3R1, ADCY7, PLCB2, CACNA1S, ADCY4, PRKCB, PLA2G4A, PRKAG2, JUN, RHOA, CAMK2G, PIK3R2, CAMK2B, CAMK2D, PRKAG3, PPP1CC, PLCB1, PRKCA, MAP2K1, KCNJ9, ITPR1, PPP3CB, KCNJ6, PIK3CD, NOS3, MAPK1, FOS, PRKAB1, GNAI3, PRKAA1, ADCY3, KCNJ3, PIK3R5, PPP3CC, PRKCG, GNAQ, MAPK3, ADCY6, ADCY8, RAF1, PIK3CB, PRKAA2, PIK3CA, ACTG1, KRAS, PLA2G4B, EGFR, NRAS 842 158 6910 3.6877987913046093 3.5062962665656005E-22 1.2986282468761484E-23 1.872603960757191E-21 KEGG_PATHWAY hsa05215:Prostate cancer 51 4.657534246575342 5.453936006855601E-24 CCND1, IGF1, PIK3CG, FOXO1, PIK3R1, MDM2, PIK3R3, GRB2, CDKN1A, INS, MAP2K2, PDGFB, CASP9, BCL2, RB1, NFKBIA, CCNE1, PDGFA, SOS1, CREB1, TP53, IGF1R, TGFA, RELA, SOS2, EGF, PIK3R2, E2F3, CDKN1B, CREBBP, MAP2K1, CTNNB1, AR, HSP90AA1, PIK3CD, HSP90B1, ERBB2, MAPK1, EP300, ATF4, PIK3R5, MAPK3, CDK2, NFKB1, RAF1, PIK3CB, PIK3CA, KRAS, EGFR, AKT1, NRAS 842 88 6910 4.756127186352839 1.3198525136590554E-21 4.713758977353769E-23 7.048922443493808E-21 KEGG_PATHWAY hsa04370:VEGF signaling pathway 42 3.8356164383561646 6.872186506915401E-24 SRC, CDC42, PRKCA, PIK3CG, PPP3CA, MAP2K1, MAPK12, PPP3CB, PIK3R1, PIK3CD, PIK3R3, RAC2, PLCG2, NOS3, MAPK11, MAPK1, RAC3, MAP2K2, CASP9, PPP3R1, MAPK13, SHC2, PIK3R5, PPP3CC, PRKCG, PLCG1, MAPK3, PRKCB, PLA2G4A, RAC1, RAF1, PTK2, PIK3CB, PXN, PIK3CA, VEGFA, PLA2G4B, MAPK14, PIK3R2, KRAS, NRAS, AKT1 842 61 6910 5.650480900276469 1.663069134673527E-21 5.734721154046646E-23 8.881935842954571E-21 KEGG_PATHWAY hsa04611:Platelet activation 62 5.662100456621005 3.8076074164344346E-23 SRC, COL5A1, PRKACG, ACTB, PIK3CG, PLCB3, MAPK12, COL3A1, BTK, ADCY1, ADCY2, PLCB4, PPP1CA, PIK3R1, PIK3R3, COL2A1, PLCG2, MAPK11, ADCY5, PRKACA, GNAI1, PRKACB, MAPK13, FGG, ADCY7, PLCB2, ITGB1, ADCY4, PLA2G4A, COL1A2, RHOA, MAPK14, PIK3R2, PPP1CC, PLCB1, ITPR1, PTGIR, PRKCI, LCP2, PIK3CD, NOS3, SYK, MAPK1, FYN, LYN, RAP1B, GNAI3, ADCY3, PIK3R5, COL1A1, GNAQ, MAPK3, ADCY6, ADCY8, VASP, PIK3CB, PIK3CA, ACTG1, COL11A1, PLA2G4B, AKT1, PRKCZ 842 130 6910 3.913941165722638 9.214409947771331E-21 3.071469982590444E-22 4.921130233281223E-20 KEGG_PATHWAY hsa04066:HIF-1 signaling pathway 52 4.748858447488584 4.206236952318764E-22 IGF1, TLR4, PIK3CG, RPS6, PIK3R1, PIK3R3, PLCG2, CAMK2A, CDKN1A, INS, INSR, MAP2K2, BCL2, ANGPT1, ANGPT2, VHL, PRKCB, IGF1R, CAMK2G, RELA, EGF, VEGFA, CAMK2B, PIK3R2, RPS6KB2, CAMK2D, CDKN1B, RPS6KB1, PRKCA, CREBBP, MAP2K1, IL6, IL6R, PIK3CD, ERBB2, NOS3, MAPK1, IFNG, EP300, PIK3R5, PRKCG, HIF1A, PLCG1, MAPK3, NFKB1, ANGPT4, EIF4E, PIK3CB, PIK3CA, EGFR, AKT1, STAT3 842 98 6910 4.354549420718406 1.0179093424611409E-19 3.283578524068196E-21 5.436337723541928E-19 KEGG_PATHWAY hsa04024:cAMP signaling pathway 76 6.940639269406393 3.192615402331246E-21 ADORA1, SSTR5, PRKACG, PIK3CG, MAPK10, ADCY1, ADCY2, PPP1CA, PIK3R1, CALM3, PIK3R3, RAC2, CAMK2A, ADCY5, PRKACA, DRD1, GNAI1, MAP2K2, PPARA, PRKACB, ADCY7, PAK1, CACNA1S, ATP2B4, NFKBIA, VAV2, ADCY4, RAC1, CREB1, GABBR2, JUN, TIAM1, VAV1, RHOA, GABBR1, MAPK9, CAMK2G, RELA, DRD2, PIK3R2, CAMK2B, CAMK2D, MAPK8, PPP1CC, MAP2K1, CREBBP, ADRB1, ADORA2A, FFAR2, CFTR, SSTR2, VAV3, ADCY10, PIK3CD, MAPK1, RAC3, GLI1, FOS, RAP1B, GNAI3, ADCY3, PIK3R5, GLI3, EP300, MAPK3, ATP2B1, NFKB1, EDNRA, ADCY6, ADCY8, RAF1, ADRB2, TSHR, PIK3CB, PIK3CA, AKT1 842 198 6910 3.150027591832817 7.726129273641616E-19 2.414415398013005E-20 4.126285738345402E-18 KEGG_PATHWAY hsa05212:Pancreatic cancer 41 3.744292237442922 3.29702643176095E-21 CCND1, CDC42, PIK3CG, MAP2K1, MAPK10, SMAD3, PIK3R1, PIK3CD, PIK3R3, RAC2, ERBB2, MAPK1, RAC3, CASP9, RB1, JAK1, PIK3R5, MAPK3, NFKB1, RAC1, TP53, RAF1, BCL2L1, SMAD2, PIK3CB, SMAD4, PIK3CA, CDK4, TGFA, RELA, MAPK9, EGF, VEGFA, KRAS, PIK3R2, EGFR, RAD51, E2F3, AKT1, STAT3, MAPK8 842 65 6910 5.17650283208478 7.978803964861499E-19 2.4178193832913635E-20 4.261231445036899E-18 KEGG_PATHWAY hsa04662:B cell receptor signaling pathway 42 3.8356164383561646 6.840650372339611E-21 PPP3CA, PIK3CG, MAP2K1, BTK, PPP3CB, VAV3, PIK3R1, PIK3CD, PTPN6, GRB2, PIK3R3, RAC2, PLCG2, SYK, MAPK1, RAC3, FOS, MAP2K2, PPP3R1, LYN, PIK3R5, NFKBIB, NFKBIA, PPP3CC, VAV2, MAPK3, NFKB1, SOS1, BLNK, RAC1, RAF1, JUN, INPP5D, PIK3CB, VAV1, PIK3CA, RELA, SOS2, KRAS, PIK3R2, NRAS, AKT1 842 69 6910 4.99535267995456 1.6554373901061859E-18 4.8689335003123114E-20 8.841177064979746E-18 KEGG_PATHWAY hsa04725:Cholinergic synapse 54 4.931506849315069 1.0896117566219168E-20 PRKACG, PIK3CG, PLCB3, ADCY2, ADCY1, PLCB4, PIK3R1, PIK3R3, CAMK2A, CHRM4, ADCY5, PRKACA, GNAI1, PRKACB, GNA11, BCL2, ADCY7, PLCB2, CACNA1S, ADCY4, PRKCB, CREB1, CAMK2G, CAMK2B, PIK3R2, CAMK2D, PRKCA, PLCB1, MAP2K1, CACNA1A, ITPR1, KCNJ6, PIK3CD, JAK2, MAPK1, FYN, ACHE, FOS, GNAI3, ADCY3, KCNJ3, ATF4, PIK3R5, PRKCG, GNAQ, MAPK3, ADCY6, ADCY8, CACNA1B, PIK3CB, PIK3CA, KRAS, NRAS, AKT1 842 111 6910 3.9924247287667716 2.6368604510250385E-18 7.533887002928682E-20 1.408265288828552E-17 KEGG_PATHWAY hsa04071:Sphingolipid signaling pathway 56 5.114155251141553 2.2512061684602872E-20 PPP2CB, ADORA1, PPP2R1A, PIK3CG, PLCB3, MAPK12, MAPK10, PLCB4, PRKCE, PIK3R1, PIK3R3, RAC2, MAPK11, MAP2K2, GNAI1, MAPK13, BCL2, SPTLC1, PLCB2, PRKCB, RAC1, TP53, PPP2CA, RHOA, RELA, MAPK9, MAPK14, PIK3R2, MAPK8, PRKCA, PLCB1, TNF, MAP2K1, PIK3CD, NOS3, MAPK1, FYN, RAC3, GNAI3, GAB2, PIK3R5, PRKCG, GNAQ, MAPK3, NFKB1, TRAF2, BDKRB2, RAF1, OPRD1, PIK3CB, PIK3CA, CTSD, KRAS, NRAS, AKT1, PRKCZ 842 120 6910 3.829770387965162 5.447918927673895E-18 1.5133108132427486E-19 2.909564334059771E-17 KEGG_PATHWAY hsa05210:Colorectal cancer 39 3.5616438356164384 4.045459999649005E-20 CCND1, APC2, PIK3CG, MLH1, MAP2K1, MAPK10, SMAD3, CTNNB1, PIK3R1, PIK3CD, PIK3R3, RAC2, APC, MAPK1, RAC3, MYC, FOS, CASP9, BCL2, PIK3R5, MAPK3, RAC1, TP53, CYCS, BIRC5, RAF1, JUN, SMAD2, PIK3CB, SMAD4, PIK3CA, RHOA, MAPK9, CASP3, KRAS, PIK3R2, MSH2, AKT1, MAPK8 842 62 6910 5.162248103593594 9.790013199150593E-18 2.645949513283944E-19 5.22854205658767E-17 KEGG_PATHWAY hsa05142:Chagas disease (American trypanosomiasis) 51 4.657534246575342 9.528910159342071E-20 PPP2CB, PPP2R1A, TLR4, PIK3CG, PLCB3, MAPK12, MAPK10, SMAD3, ADCY1, PLCB4, PIK3R1, PIK3R3, MAPK11, C3, GNAI1, MAPK13, GNA11, PLCB2, CASP8, NFKBIA, JUN, PPP2CA, RELA, MAPK9, MAP2K4, TLR2, MAPK14, PIK3R2, MAPK8, MYD88, PLCB1, TNF, IL6, PIK3CD, IRAK1, FADD, IL10, MAPK1, FOS, TRAF6, IFNG, GNAI3, PIK3R5, GNAQ, MAPK3, NFKB1, BDKRB2, SMAD2, PIK3CB, PIK3CA, AKT1 842 104 6910 4.024415311529326 2.305996258560781E-17 6.068411206738898E-19 1.231560997411623E-16 KEGG_PATHWAY hsa04666:Fc gamma R-mediated phagocytosis 45 4.10958904109589 2.241683233349282E-19 CDC42, RPS6KB1, PRKCA, PIK3CG, WASF2, MAP2K1, PRKCE, CRKL, PIK3R1, VAV3, PIK3CD, PIK3R3, RAC2, PLCG2, LIMK1, SYK, MAPK1, HCK, CRK, WASL, LYN, GAB2, ARPC5L, WASF3, WAS, PIK3R5, PAK1, PTPRC, PRKCG, VAV2, PLCG1, MAPK3, PRKCB, PRKCD, LAT, RAC1, RAF1, INPP5D, VASP, PIK3CB, VAV1, PIK3CA, PIK3R2, RPS6KB2, AKT1 842 84 6910 4.396420088225314 5.424873424705263E-17 1.3909931858218622E-18 2.8972564465180905E-16 KEGG_PATHWAY hsa04919:Thyroid hormone signaling pathway 53 4.840182648401827 3.2745907786252465E-19 CCND1, SRC, HDAC2, ACTB, PIK3CG, PRKACG, PLCB3, FOXO1, PLCB4, PIK3R1, MDM2, PIK3R3, PLCG2, PRKACA, MAP2K2, PRKACB, CASP9, PLCB2, KAT2A, PRKCB, KAT2B, TP53, PIK3R2, PLCB1, NCOR1, PRKCA, HDAC3, MAP2K1, CREBBP, CTNNB1, HDAC1, NOTCH1, PIK3CD, ITGAV, MAPK1, MYC, RXRA, THRB, EP300, PIK3R5, THRA, HIF1A, PRKCG, PLCG1, MAPK3, RAF1, ESR1, PIK3CB, PIK3CA, ACTG1, KRAS, AKT1, NRAS 842 114 6910 3.815372754927699 7.924509684273097E-17 1.981127421068274E-18 4.2322345556850787E-16 KEGG_PATHWAY hsa05221:Acute myeloid leukemia 36 3.287671232876712 5.038449176666799E-19 CCND1, RPS6KB1, PIK3CG, MAP2K1, STAT5A, PIK3R1, RARA, PIK3CD, GRB2, PIK3R3, STAT5B, MAPK1, MYC, MAP2K2, FLT3, PIK3R5, RUNX1, MAPK3, JUP, NFKB1, SPI1, SOS1, KIT, RAF1, PIK3CB, PIK3CA, RELA, ZBTB16, SOS2, KRAS, PIK3R2, RPS6KB2, STAT3, NRAS, AKT1, PML 842 56 6910 5.275704105870377 1.2193047007533654E-16 2.973913904276501E-18 6.511927796212923E-16 KEGG_PATHWAY hsa05223:Non-small cell lung cancer 36 3.287671232876712 5.038449176666799E-19 RASSF5, CCND1, PRKCA, PIK3CG, MAP2K1, PIK3R1, PIK3CD, PIK3R3, GRB2, PLCG2, ERBB2, MAPK1, MAP2K2, CASP9, RB1, RXRA, PIK3R5, PRKCG, PLCG1, MAPK3, PRKCB, SOS1, TP53, RAF1, PIK3CB, PIK3CA, CDK4, TGFA, SOS2, EGF, PIK3R2, KRAS, EGFR, E2F3, NRAS, AKT1 842 56 6910 5.275704105870377 1.2193047007533654E-16 2.973913904276501E-18 6.511927796212923E-16 KEGG_PATHWAY hsa04110:Cell cycle 55 5.0228310502283104 8.945097372799316E-19 CCNB2, CCND1, HDAC2, CDC20, YWHAB, SMAD3, PLK1, MDM2, ESPL1, CDC27, CDKN1A, SMC3, RB1, ANAPC11, CCNE1, ABL1, TP53, CCNB1, SKP2, RAD21, STAG1, SMC1A, E2F3, CDKN1B, ANAPC7, MAD2L1, ANAPC2, CCND2, PTTG1, CREBBP, PTTG2, CDK1, YWHAG, CDC23, ATM, HDAC1, YWHAQ, SKP1, MAD2L2, MYC, MCM2, CCND3, PCNA, YWHAZ, SMC1B, EP300, CCNA1, CHEK2, CDK2, STAG2, MCM7, SMAD2, ATR, SMAD4, CDK4 842 124 6910 3.6400467397134317 2.1647135642174345E-16 5.154079914803416E-18 1.1561062973805444E-15 KEGG_PATHWAY hsa04630:Jak-STAT signaling pathway 60 5.47945205479452 1.1462394037104087E-18 CCND1, IL2RG, PIK3CG, STAT6, SOCS1, SOCS5, STAT5A, JAK3, PIK3R1, SOCS7, PTPN6, SOCS4, PIK3R3, GRB2, PIAS3, PIAS2, PIAS4, SOS1, CISH, BCL2L1, IL12RB1, IL4, STAT2, IL23R, IL2RA, SOS2, PIK3R2, SOCS2, PIAS1, SOCS3, IL21R, IL21, CCND2, GHR, CREBBP, IL3, IL6, IL6R, PIK3CD, JAK2, STAT5B, STAM2, PTPN11, IL10, GH1, MYC, CCND3, IFNG, JAK1, EP300, PIK3R5, PRLR, EPOR, PIK3CB, TYK2, PIK3CA, STAT4, IL6ST, AKT1, STAT3 842 145 6910 3.395855516422311 2.773899356979189E-16 6.450928737160905E-18 1.4814535132562989E-15 KEGG_PATHWAY hsa04650:Natural killer cell mediated cytotoxicity 54 4.931506849315069 2.1601916881277615E-18 PTK2B, SH3BP2, PIK3CG, PPP3CA, CD48, PIK3R1, PTPN6, PIK3R3, GRB2, RAC2, PLCG2, MAP2K2, PPP3R1, SHC1, SHC2, PAK1, VAV2, PRKCB, LAT, SOS1, RAC1, VAV1, SHC3, SHC4, SOS2, PIK3R2, TNFRSF10B, LCK, PRKCA, TNF, MAP2K1, PPP3CB, LCP2, VAV3, PIK3CD, PTPN11, SYK, MAPK1, RAC3, FYN, IFNG, KIR2DL2, PIK3R5, PPP3CC, PRKCG, PLCG1, MAPK3, RAF1, PIK3CB, PIK3CA, CASP3, KRAS, GZMB, NRAS 842 122 6910 3.6324520073205875 5.227663885269183E-16 1.1881054284702688E-17 2.791932955126752E-15 KEGG_PATHWAY hsa04520:Adherens junction 40 3.65296803652968 2.859486445212087E-18 CSNK2A2, SRC, CDC42, ACTB, CSNK2B, CREBBP, WASF2, CTNNA1, SMAD3, CSNK2A1, CTNNB1, ACTN2, ACTN1, PTPRF, PTPN6, CDH1, RAC2, CTNND1, ERBB2, MAPK1, RAC3, FYN, INSR, ACTN4, YES1, TJP1, WASL, WASF3, ACTN3, WAS, EP300, PTPRJ, MAPK3, RAC1, IGF1R, SMAD2, SMAD4, RHOA, ACTG1, EGFR 842 71 6910 4.623465257100799 6.91995719741325E-16 1.5377682660918335E-17 3.695734265159204E-15 KEGG_PATHWAY hsa05211:Renal cell carcinoma 38 3.4703196347031966 4.237866668741063E-18 CDC42, EPAS1, PIK3CG, CREBBP, MAP2K1, RAPGEF1, CRKL, PIK3R1, PIK3CD, GRB2, PIK3R3, HGF, PTPN11, MAPK1, MAP2K2, CRK, PDGFB, RAP1B, EP300, PAK1, PIK3R5, VHL, HIF1A, MAPK3, SOS1, RAC1, GAB1, RAF1, JUN, PIK3CB, PIK3CA, TGFA, VEGFA, SOS2, KRAS, PIK3R2, NRAS, AKT1 842 65 6910 4.797734332176137 1.0255637338353372E-15 2.229486377902907E-17 5.477217451080028E-15 KEGG_PATHWAY hsa04720:Long-term potentiation 38 3.4703196347031966 8.511941099756486E-18 PPP1CC, PRKCA, PLCB1, PRKACG, PPP3CA, CREBBP, PLCB3, MAP2K1, ITPR1, ADCY1, PLCB4, PPP3CB, PPP1CA, CALM3, CAMK2A, MAPK1, PRKACA, MAP2K2, PRKACB, PPP3R1, RAP1B, PLCB2, ATF4, EP300, RPS6KA3, PPP3CC, PRKCG, GNAQ, MAPK3, PRKCB, ADCY8, RAF1, CAMK2G, GRM1, CAMK2B, KRAS, NRAS, CAMK2D 842 66 6910 4.7250413877492266 2.0598897461410696E-15 4.3827441407256796E-17 1.1001231510665107E-14 KEGG_PATHWAY hsa04261:Adrenergic signaling in cardiomyocytes 59 5.3881278538812785 8.713931168492654E-18 PPP2CB, SCN5A, PPP2R1A, PRKACG, PIK3CG, PLCB3, MAPK12, ADCY1, ADCY2, PLCB4, PPP1CA, CALM3, PIK3R1, PIK3R3, MAPK11, CAMK2A, ADCY5, PRKACA, GNAI1, PRKACB, MAPK13, BCL2, ADCY7, PLCB2, CACNA1S, ATP2B4, ADCY4, CREB1, TPM1, PPP2CA, CAMK2G, CAMK2B, MAPK14, PIK3R2, CAMK2D, PPP1CC, PRKCA, PLCB1, ADRB1, PIK3CD, MAPK1, ACTC1, GNAI3, ADCY3, ATF4, PIK3R5, MYL3, ATF2, GNAQ, MAPK3, ATP2B1, AGTR1, ADCY6, ADCY8, ADRB2, PIK3CB, PIK3CA, RPS6KA5, AKT1 842 146 6910 3.3163862948622 2.1087713427752224E-15 4.393273630781713E-17 1.1262292939894841E-14 KEGG_PATHWAY hsa05146:Amoebiasis 49 4.474885844748858 1.1472067754719888E-17 COL4A3, FN1, COL5A1, PLCB1, PRKCA, TNF, TLR4, PRKACG, PIK3CG, PLCB3, COL3A1, IL6, COL4A5, ADCY1, ACTN2, COL4A1, PLCB4, ACTN1, PIK3R1, PIK3CD, PIK3R3, COL2A1, IL10, LAMC1, ACTN4, PRKACA, PRKACB, GNA11, IFNG, PLCB2, ACTN3, PIK3R5, PRKCG, COL1A1, GNAQ, NFKB1, PRKCB, LAMA1, COL1A2, CTSG, LAMA5, PTK2, PIK3CB, PIK3CA, RELA, CASP3, COL11A1, PIK3R2, TLR2 842 106 6910 3.793640478644736 2.776240396642213E-15 5.665796727841251E-17 1.4827037898478895E-14 KEGG_PATHWAY hsa04022:cGMP-PKG signaling pathway 63 5.7534246575342465 2.253687244724334E-17 ADORA1, PPP3CA, PIK3CG, PLCB3, IRS1, ADCY1, ADCY2, PLCB4, PPP1CA, PRKCE, CALM3, PIK3R1, PIK3R3, ADRB3, IRS4, ADCY5, INS, INSR, GNAI1, MAP2K2, PPP3R1, GNA11, ADCY7, PLCB2, CACNA1S, ATP2B4, ADCY4, CREB1, RHOA, EDNRB, PIK3R2, PPP1CC, PLCB1, MAP2K1, ITPR1, ADRB1, PPP3CB, PIK3CD, NOS3, MAPK1, SRF, GNAI3, ADCY3, ATF4, PIK3R5, PPP3CC, ATF2, GNAQ, MAPK3, ATP2B1, AGTR1, EDNRA, BDKRB2, ADCY6, ADCY8, IRS2, RAF1, OPRD1, ADRB2, VASP, PIK3CB, PIK3CA, AKT1 842 166 6910 3.114572303465644 5.4539231322328885E-15 1.0907846264465777E-16 2.912770993276101E-14 KEGG_PATHWAY hsa05100:Bacterial invasion of epithelial cells 41 3.744292237442922 2.6584858521318153E-17 FN1, ITGA5, SRC, CDC42, CBL, ACTB, PIK3CG, WASF2, CTNNA1, CTNNB1, CAV1, CRKL, PIK3R1, PIK3CD, CDH1, PIK3R3, RHOG, MAD2L2, CRK, SHC1, WASL, SHC2, ARPC5L, WAS, PIK3R5, ITGB1, CBLB, RAC1, GAB1, CBLC, PTK2, PIK3CB, PXN, SHC3, ILK, PIK3CA, SHC4, RHOA, ACTG1, PIK3R2, CLTB 842 78 6910 4.313752360070651 6.433535762158993E-15 1.261477600423332E-16 3.4359516806297694E-14 KEGG_PATHWAY hsa05213:Endometrial cancer 33 3.0136986301369864 3.264747732301935E-17 CCND1, APC2, MLH1, PIK3CG, MAP2K1, CTNNA1, CTNNB1, PIK3R1, PIK3CD, CDH1, PIK3R3, GRB2, ERBB2, APC, MAPK1, MYC, MAP2K2, CASP9, PIK3R5, MAPK3, SOS1, TP53, RAF1, PIK3CB, PIK3CA, ILK, EGF, SOS2, KRAS, PIK3R2, EGFR, NRAS, AKT1 842 52 6910 5.208066873743833 7.900689512170682E-15 1.5193633677251314E-16 4.219512941413564E-14 KEGG_PATHWAY hsa04010:MAPK signaling pathway 81 7.397260273972603 7.189665983511547E-17 PPP3CA, PRKACG, FGF10, MAPK12, MAPK10, STK3, FGF2, HSPA8, GRB2, RAC2, MAPK11, PRKACA, MAP2K2, PRKACB, PDGFB, PPP3R1, MAPK13, RASA1, DUSP3, PAK1, CACNA1S, FGF7, FLNA, PRKCB, SOS1, PDGFA, PLA2G4A, RAC1, TP53, JUN, ARRB2, MAPK9, RELA, MAP2K4, EGF, SOS2, MAPK14, ARRB1, NGF, MAPK8, CDC42, PRKCA, TNF, MAP2K1, CACNA1A, FGF1, PPP3CB, PPM1A, CRKL, MAPK1, RAC3, MYC, SRF, NR4A1, FOS, TRAF6, CRK, RPS6KA4, RAP1B, FGF13, ATF4, RPS6KA3, PPP3CC, PRKCG, ATF2, MAPK3, NFKB1, TRAF2, RAF1, CACNA1B, MAP3K2, HSPA1A, CASP3, KRAS, FGF4, RPS6KA5, PLA2G4B, DAXX, EGFR, NRAS, AKT1 842 255 6910 2.606818499371245 2.6867397195928788E-14 5.551115123125783E-16 1.4432899320127035E-13 KEGG_PATHWAY hsa05164:Influenza A 64 5.844748858447488 7.300185745313233E-17 TLR4, ACTB, PIK3CG, MAPK12, MAPK10, HSPA8, PIK3R1, PIK3R3, EIF2AK1, EIF2AK4, MAPK11, MAP2K2, CASP9, MAPK13, NFKBIA, PRKCB, JUN, STAT2, RELA, MAPK9, MAP2K4, PIK3R2, MAPK14, SOCS3, MAPK8, MYD88, TNFRSF10B, PRKCA, TNF, MAP2K1, CREBBP, IKBKE, IL6, PIK3CD, JAK2, MAPK1, KPNA2, IL18, DNAJC3, PABPN1, IFNG, JAK1, PIK3R5, EP300, NFKBIB, EIF2AK2, ATF2, MAPK3, NFKB1, NUP98, DDX39B, CYCS, RAF1, NXF1, PIK3CB, TYK2, EIF2AK3, HSPA1A, XPO1, PIK3CA, ACTG1, EIF2S1, AKT1, PML 842 174 6910 3.0185382368198326 2.6867397195928788E-14 4.440892098500626E-16 1.4432899320127035E-13 KEGG_PATHWAY hsa05160:Hepatitis C 54 4.931506849315069 1.999693653376345E-16 EIF3E, PPP2CB, PPP2R1A, PIK3CG, MAPK12, MAPK10, PIK3R1, PSME3, PIK3R3, GRB2, EIF2AK1, MAPK11, EIF2AK4, CDKN1A, PPARA, MAPK13, NFKBIA, SOS1, TP53, STAT2, PPP2CA, RELA, MAPK9, SOS2, EGF, MAPK14, PIK3R2, PIAS1, SOCS3, MAPK8, IRF1, TNF, IKBKE, PIK3CD, MAPK1, TRAF6, RXRA, JAK1, PIK3R5, EIF2AK2, MAPK3, NFKB1, TRAF2, RAF1, PIK3CB, TYK2, EIF2AK3, PIK3CA, EIF2S1, KRAS, EGFR, AKT1, NRAS, STAT3 842 133 6910 3.33202364581287 5.3734794391857577E-14 9.992007221626409E-16 2.886579864025407E-13 KEGG_PATHWAY hsa05231:Choline metabolism in cancer 46 4.200913242009133 2.604014576820962E-16 RPS6KB1, PRKCA, PIK3CG, WASF2, MAP2K1, MAPK10, PIK3R1, PIK3CD, GRB2, PIK3R3, RAC2, MAPK1, RAC3, FOS, MAP2K2, PDGFB, WASL, WASF3, WAS, PIK3R5, PRKCG, HIF1A, PLCG1, MAPK3, PRKCB, PDGFA, SOS1, PLA2G4A, RAC1, TSC1, RAF1, JUN, PIK3CB, PIK3CA, MAPK9, EGF, SOS2, PLA2G4B, KRAS, PIK3R2, EGFR, SP1, RPS6KB2, NRAS, AKT1, MAPK8 842 101 6910 3.7376825568542604 5.3734794391857577E-14 9.992007221626409E-16 2.886579864025407E-13 KEGG_PATHWAY hsa05145:Toxoplasmosis 50 4.5662100456621 5.03160823906899E-16 TLR4, PIK3CG, MAPK12, MAPK10, SOCS1, HSPA8, PIK3R1, PIK3R3, MAPK11, GNAI1, MAPK13, CASP9, BCL2, ITGB1, CASP8, NFKBIA, BCL2L1, LAMA5, RELA, MAPK9, TLR2, MAPK14, PIK3R2, MAPK8, MYD88, TNF, PIK3CD, JAK2, IRAK1, IL10, MAPK1, LAMC1, TRAF6, IFNG, GNAI3, JAK1, PIK3R5, NFKBIB, MAPK3, NFKB1, LAMA1, CYCS, CCR5, PIK3CB, TYK2, HSPA1A, PIK3CA, CASP3, AKT1, STAT3 842 118 6910 3.47739442006522 1.3433698597964394E-13 2.3314683517128287E-15 7.216449660063518E-13 KEGG_PATHWAY hsa04931:Insulin resistance 47 4.292237442922374 1.2192037262708572E-15 PRKAG3, PPP1CC, RPS6KB1, TNF, PIK3CG, MAPK10, IL6, IRS1, FOXO1, PRKCE, PPP1CA, PTPRF, SLC2A2, PIK3R1, PIK3CD, PIK3R3, PRKAG1, NOS3, PRKAB2, PTPN11, INS, INSR, PPARA, PRKAB1, PRKAA1, PIK3R5, RPS6KA3, NFKBIA, PRKCD, NFKB1, PRKAG2, CREB1, IRS2, SLC2A4, PIK3CB, PRKAA2, PIK3CA, MAPK9, RELA, CD36, PIK3R2, RPS6KB2, STAT3, AKT1, SOCS3, MAPK8, PRKCZ 842 108 6910 3.571412861792909 2.9554136915521667E-13 5.10702591327572E-15 1.5765166949677223E-12 KEGG_PATHWAY hsa05222:Small cell lung cancer 41 3.744292237442922 1.4294360527409514E-15 COL4A3, CCND1, FN1, CKS1B, PIK3CG, COL4A5, COL4A1, PIK3R1, PIK3CD, PIK3R3, ITGAV, MYC, LAMC1, TRAF6, CASP9, BCL2, RB1, RXRA, PIAS2, ITGB1, PIK3R5, NFKBIA, CCNE1, NFKB1, CDK2, LAMA1, TRAF2, TP53, CYCS, TRAF4, BCL2L1, SKP2, LAMA5, PTK2, PIK3CB, PIK3CA, CDK4, RELA, PIK3R2, E2F3, AKT1 842 85 6910 3.9585021657118906 3.4927616354707425E-13 5.88418203051333E-15 1.865174681370263E-12 KEGG_PATHWAY hsa05218:Melanoma 37 3.3789954337899544 1.9115410241142E-15 CCND1, IGF1, PIK3CG, MAP2K1, FGF10, FGF1, FGF2, PIK3R1, CDH1, PIK3CD, PIK3R3, MDM2, HGF, MAPK1, CDKN1A, MAP2K2, PDGFB, RB1, FGF13, PIK3R5, FGF7, MAPK3, PDGFA, TP53, IGF1R, RAF1, PIK3CB, PIK3CA, CDK4, EGF, KRAS, PIK3R2, FGF4, EGFR, E2F3, NRAS, AKT1 842 71 6910 4.276705362818239 4.567457523307894E-13 7.66053886991358E-15 2.4424906541753444E-12 KEGG_PATHWAY hsa04930:Type II diabetes mellitus 30 2.73972602739726 2.2749962584380487E-15 PIK3CG, TNF, CACNA1A, MAPK10, IRS1, SOCS1, PRKCE, PIK3R1, SLC2A2, PIK3CD, SOCS4, PIK3R3, MAPK1, IRS4, INS, INSR, PIK3R5, MAPK3, PRKCD, IRS2, SLC2A4, CACNA1B, PIK3CB, PIK3CA, MAPK9, PIK3R2, SOCS3, SOCS2, PRKCZ, MAPK8 842 48 6910 5.129156769596199 5.373479439185758E-13 8.770761894538737E-15 2.864375403532904E-12 KEGG_PATHWAY hsa04380:Osteoclast differentiation 52 4.748858447488584 2.8692013397572E-15 PIK3CG, PPP3CA, MAPK12, MAPK10, BTK, SOCS1, PIK3R1, PIK3R3, GRB2, PLCG2, MAPK11, MAPK13, PPP3R1, NFKBIA, SPI1, BLNK, CREB1, RAC1, JUN, STAT2, RELA, MAPK9, MAPK14, PIK3R2, SOCS3, MAPK8, LCK, CSF1R, TNF, MAP2K1, PPP3CB, TEC, LCP2, PIK3CD, SYK, MAPK1, FYN, FOS, TRAF6, IFNG, GAB2, JAK1, PIK3R5, PPP3CC, MAPK3, NFKB1, TRAF2, CSF1, PIK3CB, TYK2, PIK3CA, AKT1 842 131 6910 3.2576018567206395 6.985523270941485E-13 1.1213252548714081E-14 3.730349362740526E-12 KEGG_PATHWAY hsa04810:Regulation of actin cytoskeleton 69 6.301369863013699 5.097622100848391E-15 ITGA5, SRC, ACTB, PIK3CG, WASF2, FGF10, PPP1CA, FGF2, ITGB5, ITGB8, PIK3R1, EZR, PIK3R3, RAC2, LIMK1, APC, CHRM4, GIT1, INS, ACTN4, MAP2K2, PDGFB, WASL, ARPC5L, PAK1, ITGB1, VAV2, FGF7, SOS1, PDGFA, RAC1, TIAM1, VAV1, RHOA, EGF, SOS2, PIK3R2, APC2, FN1, CDC42, PPP1CC, MAP2K1, FGF1, ACTN2, ACTN1, CRKL, VAV3, PIK3CD, ITGAV, MAPK1, RAC3, CRK, FGF13, ACTN3, WAS, PIK3R5, ITGB4, MAPK3, BDKRB2, RAF1, PXN, PTK2, PIK3CB, PIK3CA, ACTG1, KRAS, FGF4, EGFR, NRAS 842 211 6910 2.6836915040920397 1.2359002710127243E-12 1.965094753586527E-14 6.6058269965196814E-12 KEGG_PATHWAY hsa05162:Measles 52 4.748858447488584 5.9951728406079564E-15 IL2RG, CCND1, PIK3CG, TLR4, STAT5A, JAK3, PIK3R1, HSPA8, PIK3R3, EIF2AK1, EIF2AK4, NFKBIA, CCNE1, TP53, IL4, STAT2, RELA, IL2RA, PIK3R2, TLR2, CDKN1B, CSNK2A2, MYD88, TNFRSF10B, CCND2, CSNK2B, IKBKE, CSNK2A1, IL6, PIK3CD, JAK2, IRAK1, STAT5B, FYN, CCND3, TRAF6, IFNG, JAK1, PIK3R5, NFKBIB, EIF2AK2, CDK2, NFKB1, PIK3CB, EIF2AK3, TYK2, CDK4, PIK3CA, HSPA1A, EIF2S1, STAT3, AKT1 842 133 6910 3.2086153626346148 1.4508394485801546E-12 2.2648549702353193E-14 7.749356711883593E-12 KEGG_PATHWAY hsa04923:Regulation of lipolysis in adipocytes 32 2.922374429223744 7.301002973564511E-15 ADORA1, PRKACG, PIK3CG, ADRB1, IRS1, ADCY1, ADCY2, PIK3R1, PIK3CD, PIK3R3, ADRB3, IRS4, ADCY5, INS, PRKACA, INSR, GNAI1, PRKACB, GNAI3, ADCY7, ADCY3, PIK3R5, ADCY4, ADCY6, ADCY8, IRS2, ADRB2, TSHR, PIK3CB, PIK3CA, PIK3R2, AKT1 842 56 6910 4.689514760773668 1.7732482149313E-12 2.731148640577885E-14 9.470202400052585E-12 KEGG_PATHWAY hsa04916:Melanogenesis 43 3.9269406392694064 3.9160780702500956E-14 KITLG, PRKCA, PLCB1, PRKACG, CREBBP, PLCB3, MAP2K1, CTNNB1, ADCY1, ADCY2, POMC, PLCB4, CALM3, CAMK2A, MAPK1, WNT1, ADCY5, PRKACA, MAP2K2, GNAI1, FZD8, PRKACB, GNAI3, PLCB2, ADCY7, ADCY3, EP300, PRKCG, ADCY4, GNAQ, MAPK3, PRKCB, CREB1, ADCY6, ADCY8, KIT, RAF1, EDNRB, CAMK2G, CAMK2B, KRAS, NRAS, CAMK2D 842 100 6910 3.528859857482185 9.484191210162862E-12 1.4366285938649526E-13 5.064837438339964E-11 KEGG_PATHWAY hsa04670:Leukocyte transendothelial migration 47 4.292237442922374 6.545867733504098E-14 RASSF5, CDC42, PTK2B, PRKCA, ACTB, PIK3CG, MMP9, MAPK12, CTNNA1, CXCR4, CTNNB1, ACTN2, ACTN1, PIK3R1, VAV3, EZR, PIK3CD, PIK3R3, CDH5, RAC2, PLCG2, CTNND1, PTPN11, MAPK11, ACTN4, GNAI1, MAPK13, RAP1B, GNAI3, ACTN3, PIK3R5, ITGB1, PRKCG, VAV2, PLCG1, PRKCB, RAC1, VASP, PTK2, PIK3CB, VAV1, PXN, RHOA, PIK3CA, ACTG1, MAPK14, PIK3R2 842 118 6910 3.2687507548613066 1.5851764345597985E-11 2.3658852654762086E-13 8.465450562766819E-11 KEGG_PATHWAY hsa04668:TNF signaling pathway 44 4.018264840182648 8.439148440347665E-14 PIK3CG, TNF, MMP9, MAP2K1, MAPK12, MAPK10, IL6, PIK3R1, PIK3CD, PIK3R3, FADD, MAPK11, MAPK1, FOS, CASP7, ITCH, MAPK13, RPS6KA4, ATF4, PIK3R5, CASP8, NFKBIA, ATF2, MAPK3, NFKB1, IL18R1, TRAF2, CREB1, JUN, CSF1, PIK3CB, PIK3CA, RELA, MAPK9, MAP2K4, CEBPB, CASP3, RPS6KA5, MAPK14, PIK3R2, TNFRSF1B, SOCS3, AKT1, MAPK8 842 106 6910 3.406534307354457 2.041922186890588E-11 3.0031532816110484E-13 1.0905720770892913E-10 KEGG_PATHWAY hsa04728:Dopaminergic synapse 49 4.474885844748858 1.0514483864416122E-13 PPP2CB, PPP3CA, PRKACG, PPP2R1A, MAPK12, PLCB3, MAPK10, PPP1CA, PLCB4, CALM3, CAMK2A, MAPK11, ADCY5, PRKACA, GNAI1, DRD1, PRKACB, MAPK13, PLCB2, PRKCB, CREB1, PPP2CA, MAPK9, CAMK2G, DRD2, CAMK2B, MAPK14, CAMK2D, MAPK8, PPP1CC, PLCB1, PRKCA, KCNJ9, CACNA1A, ITPR1, PPP3CB, KCNJ6, FOS, GNAI3, KCNJ3, ATF4, PPP3CC, PRKCG, GNAQ, ATF2, CACNA1B, DRD4, DRD3, AKT1 842 128 6910 3.1416085213776723 2.5443425144544562E-11 3.687050664780145E-13 1.358801959838729E-10 KEGG_PATHWAY hsa05219:Bladder cancer 26 2.374429223744292 1.4728815003780637E-13 RB1, CCND1, SRC, MMP9, MAPK3, MAP2K1, TP53, RAF1, CDH1, MDM2, ERBB2, CDK4, MAPK1, EGF, MYC, VEGFA, CDKN1A, RPS6KA5, KRAS, THBS1, MAP2K2, EGFR, E2F3, NRAS, MMP1, HBEGF 842 41 6910 5.204217600370778 3.56530360789975E-11 5.093703236980218E-13 1.904143509534606E-10 KEGG_PATHWAY hsa04310:Wnt signaling pathway 50 4.5662100456621 6.535233321769131E-13 CSNK2A2, CCND1, APC2, CCND2, BTRC, PLCB1, PRKCA, PPP3CA, CSNK2B, PRKACG, PLCB3, CREBBP, MAPK10, CSNK2A1, CTNNB1, LRP5, PPP3CB, PLCB4, CTBP1, RAC2, SKP1, APC, CAMK2A, TBL1XR1, WNT1, RAC3, MYC, PRKACA, CCND3, PRKACB, FZD8, PPP3R1, PLCB2, EP300, PPP3CC, PRKCG, TBL1X, CSNK1A1, PRKCB, MMP7, RAC1, TP53, JUN, SMAD4, RHOA, MAPK9, CAMK2G, CAMK2B, CAMK2D, MAPK8 842 138 6910 2.9734242142586664 1.5814149989523685E-10 2.227329432002989E-12 8.445799615230953E-10 KEGG_PATHWAY hsa04730:Long-term depression 31 2.8310502283105023 7.152608207574184E-13 IGF1, PPP2CB, PRKCA, PLCB1, PPP2R1A, MAP2K1, PLCB3, CACNA1A, ITPR1, CRHR1, PLCB4, NOS1, MAPK1, GNAI1, MAP2K2, LYN, GNA11, GNAI3, PLCB2, PRKCG, GNAQ, MAPK3, PRKCB, PLA2G4A, IGF1R, RAF1, PPP2CA, GRM1, KRAS, PLA2G4B, NRAS 842 60 6910 4.240102929532858 1.7307977273617325E-10 2.403854892918389E-12 9.243605880726591E-10 KEGG_PATHWAY hsa04713:Circadian entrainment 40 3.65296803652968 7.859160928317545E-13 RASD1, PRKCA, PLCB1, PRKACG, PLCB3, KCNJ9, MTNR1B, ITPR1, ADCY2, ADCY1, PLCB4, CALM3, ADCY10, KCNJ6, CAMK2A, NOS1, MAPK1, ADCY5, PRKACA, FOS, GNAI1, PRKACB, GNAI3, PLCB2, ADCY7, ADCY3, KCNJ3, PRKCG, ADCY4, GNAQ, MTNR1A, MAPK3, PRKCB, CREB1, ADCY6, ADCY8, CAMK2G, CAMK2B, RPS6KA5, CAMK2D 842 95 6910 3.455431928991124 1.901943047499799E-10 2.605360371887855E-12 1.0157652496900482E-9 KEGG_PATHWAY hsa05152:Tuberculosis 58 5.296803652968037 9.497223153424402E-13 SRC, TLR4, PPP3CA, MAPK12, MAPK10, MRC1, CALM3, LBP, CAMK2A, MAPK11, C3, CASP9, CTSS, MAPK13, PPP3R1, BCL2, CORO1A, CASP8, CREB1, TIRAP, RHOA, CAMK2G, RELA, MAPK9, CAMK2B, TLR2, MAPK14, CAMK2D, MAPK8, MYD88, TNF, CREBBP, IL6, PPP3CB, JAK2, IRAK1, FADD, PLA2R1, SYK, IL10, MAPK1, IL18, TRAF6, IFNG, JAK1, EP300, PPP3CC, VDR, RIPK2, MAPK3, NFKB1, NFYB, CYCS, RAF1, CTSD, CEBPB, CASP3, AKT1 842 177 6910 2.6891850181837698 2.2982371561397485E-10 3.105737889086413E-12 1.227418167104588E-9 KEGG_PATHWAY hsa05168:Herpes simplex infection 59 5.3881278538812785 1.2730320215187502E-12 C1QBP, MAPK10, PPP1CA, EIF2AK1, EIF2AK4, SRSF9, C3, SRPK1, CASP8, NFKBIA, USP7, POLR2A, TP53, SRSF1, HMGN1, JUN, SKP2, STAT2, RELA, MAPK9, TLR2, SOCS3, MAPK8, CSNK2A2, MYD88, PPP1CC, TNF, CSNK2B, CREBBP, IKBKE, CDK1, IL6, CSNK2A1, TAF10, JAK2, SKP1, FADD, PTPN11, FOS, TRAF6, IFNG, JAK1, EP300, NFKBIB, EIF2AK2, TBP, TBPL1, NFKB1, CDK2, TRAF2, CYCS, NXF1, TYK2, EIF2AK3, CASP3, EIF2S1, DAXX, SRSF2, PML 842 183 6910 2.6458601040977117 3.080615762485195E-10 4.107492124205692E-12 1.645261704652512E-9 KEGG_PATHWAY hsa05131:Shigellosis 31 2.8310502283105023 6.038105901434243E-12 ITGA5, CDC42, SRC, BTRC, ACTB, WASF2, MAPK12, MAPK10, CRKL, RHOG, MAPK11, MAPK1, MAD2L2, CRK, MAPK13, WASL, ARPC5L, WAS, ITGB1, NFKBIB, NFKBIA, RIPK2, MAPK3, NFKB1, ABL1, RAC1, MAPK9, RELA, ACTG1, MAPK14, MAPK8 842 64 6910 3.9750964964370543 1.461210263897783E-9 1.922639825124861E-11 7.803868662392688E-9 KEGG_PATHWAY hsa04932:Non-alcoholic fatty liver disease (NAFLD) 51 4.657534246575342 7.775866334890943E-12 PIK3CG, MAPK10, IRS1, PIK3R1, PIK3R3, PRKAG1, PRKAB2, INS, INSR, NDUFB9, PPARA, CASP7, ITCH, CASP8, NDUFA13, NDUFS8, PRKAG2, RAC1, JUN, MAPK9, RELA, PIK3R2, SOCS3, MAPK8, NDUFB5, PRKAG3, CDC42, NDUFB10, TNF, IL6, IL6R, PIK3CD, PRKAB1, NDUFA7, PRKAA1, RXRA, NDUFV1, ATF4, PIK3R5, NDUFB6, NFKB1, TRAF2, IRS2, CYCS, PIK3CB, PRKAA2, EIF2AK3, PIK3CA, EIF2S1, CASP3, AKT1 842 151 6910 2.7717827311195355 1.8817656322056564E-9 2.4438562284956333E-11 1.0049927556821103E-8 KEGG_PATHWAY hsa04723:Retrograde endocannabinoid signaling 39 3.5616438356164384 3.6677188909688746E-11 PRKCA, PLCB1, PRKACG, PLCB3, MAPK12, CACNA1A, MAPK10, KCNJ9, ITPR1, ADCY2, ADCY1, PLCB4, KCNJ6, MAPK11, ADCY5, MAPK1, PRKACA, GNAI1, PRKACB, MAPK13, GNAI3, PLCB2, ADCY7, ADCY3, KCNJ3, CACNA1S, PRKCG, ADCY4, GNAQ, MAPK3, PRKCB, ADCY6, ADCY8, CACNA1B, MAPK9, GRM1, MAPK14, CNR1, MAPK8 842 101 6910 3.168904776463395 8.875886470249839E-9 1.1379341913198004E-10 4.7403359015874E-8 KEGG_PATHWAY hsa04620:Toll-like receptor signaling pathway 40 3.65296803652968 4.4845751442771276E-11 MYD88, TLR4, PIK3CG, TNF, IKBKE, MAP2K1, MAPK12, MAPK10, SPP1, IL6, PIK3R1, PIK3CD, PIK3R3, LBP, IRAK1, MAPK11, FADD, MAPK1, FOS, MAP2K2, TRAF6, MAPK13, PIK3R5, CASP8, NFKBIA, MAPK3, NFKB1, RAC1, JUN, TIRAP, PIK3CB, PIK3CA, RELA, MAPK9, MAP2K4, TLR2, PIK3R2, MAPK14, AKT1, MAPK8 842 106 6910 3.0968493703222335 1.0852681975315193E-8 1.3737577742034546E-10 5.7960802823942004E-8 KEGG_PATHWAY hsa04925:Aldosterone synthesis and secretion 34 3.105022831050228 5.999402304307661E-11 PRKCA, PLCB1, PRKACG, PLCB3, ITPR1, ADCY2, ADCY1, PRKCE, PLCB4, CALM3, PRKD1, CAMK2A, ADCY5, PRKACA, NR4A1, PRKACB, GNA11, PLCB2, ADCY7, ADCY3, CACNA1S, ATF4, PRKCG, GNAQ, ADCY4, ATF2, PRKCB, AGTR1, CREB1, ADCY6, ADCY8, CAMK2G, CAMK2B, CAMK2D 842 81 6910 3.4447670156300405 1.4518550250919304E-8 1.8148182956423398E-10 7.753906405838507E-8 KEGG_PATHWAY hsa04922:Glucagon signaling pathway 38 3.4703196347031966 8.373581325338894E-11 PRKAG3, PLCB1, PRKACG, PPP3CA, CREBBP, PLCB3, ITPR1, FOXO1, ADCY2, PLCB4, PPP3CB, CALM3, SLC2A2, PRKAG1, PRKAB2, CAMK2A, PRKACA, PPARA, PRKAB1, PRKACB, PPP3R1, SIRT1, PRKAA1, PLCB2, ATF4, EP300, PPP3CC, ATF2, GNAQ, PRMT1, PRKAG2, CREB1, ACACA, PRKAA2, CAMK2G, CAMK2B, CAMK2D, AKT1 842 99 6910 3.150027591832817 2.0264062428054785E-8 2.501736595661441E-10 1.0822406304455967E-7 KEGG_PATHWAY hsa04920:Adipocytokine signaling pathway 31 2.8310502283105023 9.976632687782696E-11 PRKAG3, TNF, MAPK10, IRS1, POMC, JAK2, PRKAG1, PRKAB2, PTPN11, IRS4, PPARA, PRKAB1, PRKAA1, RXRA, NFKBIB, NFKBIA, NFKB1, TRAF2, PRKAG2, IRS2, SLC2A4, PRKAA2, RELA, MAPK9, CD36, TNFRSF1B, ACSL4, SOCS3, AKT1, STAT3, MAPK8 842 70 6910 3.6343739395995924 2.414344579815264E-8 2.9443225635361614E-10 1.2894264544982548E-7 KEGG_PATHWAY hsa04020:Calcium signaling pathway 54 4.931506849315069 2.1683165648612636E-10 PTK2B, PRKACG, PPP3CA, PLCB3, ADCY2, ADCY1, PLCB4, CALM3, PLCG2, CAMK2A, ADRB3, PRKACA, DRD1, PRKACB, PTAFR, PPP3R1, GNA11, ADCY7, PLCB2, CACNA1S, ATP2B4, ADCY4, PRKCB, CAMK2G, EDNRB, GRM1, CAMK2B, CAMK2D, PRKCA, PLCB1, CACNA1A, ERBB4, ITPR1, ADRB1, ADORA2A, PPP3CB, ERBB2, NOS3, NOS1, ADCY3, HTR2A, PPP3CC, PRKCG, PLCG1, GNAQ, ATP2B1, AGTR1, EDNRA, BDKRB2, ADCY8, ADRB2, CACNA1B, LHCGR, EGFR 842 179 6910 2.47574941281068 5.2473261291652307E-8 6.322079526555058E-10 2.802434062587622E-7 KEGG_PATHWAY hsa04960:Aldosterone-regulated sodium reabsorption 22 2.009132420091324 3.538629004243345E-10 IGF1, PIK3R5, PRKCA, PRKCG, PIK3CG, MAPK3, PRKCB, IRS1, SGK1, SLC9A3R2, PIK3R1, PIK3CD, PIK3R3, NEDD4L, PIK3CB, PIK3CA, SCNN1A, MAPK1, INS, PIK3R2, INSR, KRAS 842 39 6910 4.629392776661185 8.563482756240859E-8 1.01946229236205E-9 4.5734903642014046E-7 KEGG_PATHWAY hsa04150:mTOR signaling pathway 27 2.4657534246575343 5.418310346027384E-10 PRKAA1, IGF1, PIK3R5, RPS6KB1, RPS6KA3, PRKCA, PRKCG, TNF, PIK3CG, MAPK3, RPS6, PRKCB, IRS1, EIF4B, TSC1, EIF4E, PIK3R1, PIK3CD, PIK3R3, PIK3CB, PRKAA2, PIK3CA, MAPK1, INS, PIK3R2, RPS6KB2, AKT1 842 58 6910 3.820337455975101 1.3112309937834965E-7 1.5426248056726877E-9 7.00287805521782E-7 KEGG_PATHWAY hsa04210:Apoptosis 28 2.5570776255707766 5.624609165810423E-10 TNFRSF10B, TNF, PIK3CG, IL3, ATM, PIK3R1, PIK3CD, PIK3R3, FADD, CASP7, CASP9, BCL2, PIK3R5, CASP8, NFKBIA, NFKB1, CAPN1, TRAF2, TP53, CYCS, BCL2L1, PIK3CB, PIK3CA, RELA, CASP3, PIK3R2, AKT1, NGF 842 62 6910 3.7062294077082214 1.3611554472436893E-7 1.5827390509315364E-9 7.269509105789496E-7 KEGG_PATHWAY hsa04270:Vascular smooth muscle contraction 41 3.744292237442922 6.078164498226348E-10 PLA2G2A, PPP1CC, PRKCA, PLCB1, PRKACG, PLCB3, MAP2K1, ITPR1, ADORA2A, ADCY2, ADCY1, PRKCE, PLCB4, PPP1CA, PTGIR, CALM3, ADCY5, MAPK1, PRKACA, MAP2K2, PRKACB, GNA11, PLCB2, ADCY7, ADCY3, CACNA1S, PRKCG, ADCY4, GNAQ, MAPK3, PRKCB, PRKCD, AGTR1, EDNRA, PLA2G4A, ADCY6, ADCY8, RAF1, RHOA, PLA2G4B, ARHGEF11 842 119 6910 2.827501546937065 1.470915734769207E-7 1.6907079070094255E-9 7.855704753367831E-7 KEGG_PATHWAY hsa05133:Pertussis 31 2.8310502283105023 7.695627439820949E-10 IRF1, MYD88, ITGA5, TLR4, TNF, MAPK12, MAPK10, IL6, CALM3, IRAK1, MAPK11, IL10, MAPK1, C3, GNAI1, FOS, CASP7, TRAF6, MAPK13, GNAI3, ITGB1, MAPK3, NFKB1, JUN, TIRAP, RHOA, MAPK9, RELA, CASP3, MAPK14, MAPK8 842 75 6910 3.3920823436262864 1.8623416742080678E-7 2.1162975816224616E-9 9.946189427623153E-7 KEGG_PATHWAY hsa04550:Signaling pathways regulating pluripotency of stem cells 45 4.10958904109589 9.666221042691236E-10 APC2, IGF1, PIK3CG, MAPK12, MAP2K1, SMAD1, SMAD3, CTNNB1, JAK3, FGF2, PIK3R1, PIK3CD, JAK2, GRB2, PIK3R3, APC, MAPK11, MAPK1, ID1, WNT1, MYC, BMP4, MAP2K2, SMARCAD1, FZD8, SMAD9, MAPK13, JAK1, PIK3R5, PAX6, MAPK3, KLF4, IGF1R, RAF1, SMAD2, PIK3CB, SMAD4, PIK3CA, IL6ST, KRAS, MAPK14, PIK3R2, STAT3, NRAS, AKT1 842 140 6910 2.6378520529351883 2.3392252479492726E-7 2.628343320765225E-9 1.249307701733926E-6 KEGG_PATHWAY hsa04924:Renin secretion 28 2.5570776255707766 1.337062205010213E-9 GNAI3, PLCB2, CACNA1S, ADORA1, PPP3CC, PLCB1, CTSB, PRKACG, PPP3CA, GNAQ, PLCB3, AGTR1, ITPR1, EDNRA, ADRB1, CREB1, PLCB4, PPP3CB, ADCY6, ADRB2, CALM3, AGT, ADRB3, ADCY5, PRKACA, GNAI1, PRKACB, PPP3R1 842 64 6910 3.59040973871734 3.235690095859667E-7 3.595211794937825E-9 1.728081877594434E-6 KEGG_PATHWAY hsa04152:AMPK signaling pathway 41 3.744292237442922 1.4087465829057242E-9 CCND1, PRKAG3, IGF1, PPP2CB, RPS6KB1, PPP2R1A, TBC1D1, RAB8A, PIK3CG, IRS1, FOXO1, CFTR, PIK3R1, PIK3CD, PIK3R3, PRKAG1, PRKAB2, IRS4, RAB11B, INS, INSR, PRKAB1, SIRT1, PRKAA1, PIK3R5, CCNA1, PRKAG2, CREB1, TSC1, IRS2, IGF1R, ACACA, SLC2A4, PRKAA2, PIK3CB, PPP2CA, PIK3CA, CD36, PIK3R2, RPS6KB2, AKT1 842 122 6910 2.757972820373039 3.409166106083106E-7 3.746337018384338E-9 1.8207300556127848E-6 KEGG_PATHWAY hsa04971:Gastric acid secretion 30 2.73972602739726 1.7929828304374168E-9 PRKCA, PLCB1, PRKACG, PLCB3, ITPR1, ADCY2, ADCY1, PLCB4, CFTR, CALM3, SSTR2, EZR, CAMK2A, ADCY5, PRKACA, GNAI1, PRKACB, GNAI3, PLCB2, ADCY3, ADCY7, PRKCG, GNAQ, ADCY4, PRKCB, ADCY6, ADCY8, CAMK2G, CAMK2B, CAMK2D 842 73 6910 3.3725962320632545 4.3390176163171645E-7 4.71632455312232E-9 2.317335057178127E-6 KEGG_PATHWAY hsa05130:Pathogenic Escherichia coli infection 24 2.191780821917808 4.7117776204580175E-9 TUBB, ARPC5L, ARHGEF2, CDC42, WAS, TUBA1A, ITGB1, PRKCA, ACTB, TLR4, TUBA1B, ABL1, CTNNB1, TUBB4B, TUBA3C, CDH1, EZR, TUBA4A, RHOA, ACTG1, FYN, TUBB2A, NCK1, WASL 842 51 6910 3.8619533324018445 1.1402495402323964E-6 1.2260754633786064E-8 6.089722015545362E-6 KEGG_PATHWAY hsa04911:Insulin secretion 32 2.922374429223744 5.787736261052868E-9 PRKCA, PLCB1, PRKACG, PLCB3, ADCY2, ADCY1, PLCB4, SLC2A2, CAMK2A, ADCY5, INS, PRKACA, PRKACB, GNA11, VAMP2, PLCB2, ADCY7, ADCY3, CACNA1S, ATF4, RIMS2, PRKCG, GNAQ, ADCY4, ATF2, PRKCB, CREB1, ADCY6, ADCY8, CAMK2G, CAMK2B, CAMK2D 842 85 6910 3.0895626659214757 1.4006312053505E-6 1.4900342293344693E-8 7.480341313037542E-6 KEGG_PATHWAY hsa05132:Salmonella infection 31 2.8310502283105023 1.3012042913091844E-8 MYD88, CDC42, ACTB, TLR4, WASF2, MAPK12, MAPK10, IL6, RHOG, LBP, MAPK11, MAPK1, IL18, FOS, MAPK13, WASL, TJP1, IFNG, ARPC5L, WAS, FLNA, DYNC1LI2, MAPK3, NFKB1, RAC1, JUN, MAPK9, RELA, ACTG1, MAPK14, MAPK8 842 83 6910 3.065134647855078 3.148909441419434E-6 3.314646679353217E-8 1.6817372616717563E-5 KEGG_PATHWAY hsa04918:Thyroid hormone synthesis 28 2.5570776255707766 1.3931068732078089E-8 PRKCA, PLCB1, PRKACG, PLCB3, ITPR1, ADCY2, ADCY1, PLCB4, PDIA4, HSP90B1, ADCY5, HSPA5, PRKACA, PRKACB, ADCY3, ADCY7, PLCB2, ATF4, PRKCG, GNAQ, ADCY4, ATF2, PRKCB, TG, CREB1, ADCY8, ADCY6, TSHR 842 70 6910 3.2826603325415675 3.371312976452323E-6 3.511790203081233E-8 1.8005164503787086E-5 KEGG_PATHWAY hsa05143:African trypanosomiasis 18 1.643835616438356 4.21397206728736E-8 IFNG, MYD88, PLCB2, HBA1, PRKCA, PLCB1, PRKCG, TNF, GNAQ, PLCB3, PRKCB, IL6, HBB, PLCB4, IL10, HPR, IL18, APOA1 842 33 6910 4.4763549989203195 1.0197760629826469E-5 1.0513208337226132E-7 5.4463335852350525E-5 KEGG_PATHWAY hsa04724:Glutamatergic synapse 36 3.287671232876712 9.915458015425383E-8 PRKCA, PLCB1, PRKACG, PPP3CA, PLCB3, CACNA1A, ITPR1, ADCY2, ADCY1, PPP3CB, PLCB4, ADCY5, MAPK1, PRKACA, GNAI1, PRKACB, PPP3R1, GNAI3, GRM3, PLCB2, ADCY7, ADCY3, KCNJ3, PPP3CC, PRKCG, GNAQ, ADCY4, MAPK3, PRKCB, PLA2G4A, ADCY6, ADCY8, HOMER3, GRM2, GRM1, PLA2G4B 842 114 6910 2.5915739467433427 2.399512168682616E-5 2.448510881825072E-7 1.2815194952997544E-4 KEGG_PATHWAY hsa05120:Epithelial cell signaling in Helicobacter pylori infection 26 2.374429223744292 1.037119225025225E-7 CDC42, SRC, MAPK12, MAPK10, CXCR2, PLCG2, PTPN11, MAPK11, GIT1, MAPK13, TJP1, LYN, PAK1, NFKBIA, PLCG1, NFKB1, RAC1, JUN, RELA, MAPK9, MAP2K4, CASP3, MAPK14, EGFR, HBEGF, MAPK8 842 67 6910 3.184670471868685 2.509797158578575E-5 2.5351801380413264E-7 1.3404206524736395E-4 KEGG_PATHWAY hsa04390:Hippo signaling pathway 43 3.9269406392694064 1.220660376187306E-7 CCND1, APC2, PPP2CB, PPP1CC, CCND2, BTRC, DLG3, CTGF, ACTB, PPP2R1A, WWTR1, CTNNA1, SMAD1, YWHAB, SMAD3, FGF1, YWHAG, CTNNB1, STK3, PPP1CA, PRKCI, YWHAQ, AREG, CDH1, LATS1, APC, ID1, WNT1, MYC, CCND3, BMP4, FZD8, YWHAZ, GLI2, YAP1, BIRC5, SMAD2, SMAD4, PPP2CA, ACTG1, DLG2, DLG1, PRKCZ 842 151 6910 2.3369932831007847 2.9539546603785105E-5 2.953997854104884E-7 1.5776375168474743E-4 KEGG_PATHWAY hsa04621:NOD-like receptor signaling pathway 23 2.1004566210045663 1.4421632142955248E-7 CASP8, NFKBIB, TRIP6, NFKBIA, TNF, RIPK2, MAPK12, MAPK3, NFKB1, MAPK10, IL6, HSP90AA1, HSP90B1, MAPK11, MAPK9, RELA, MAPK1, CARD6, MAPK14, IL18, TRAF6, MAPK13, MAPK8 842 55 6910 3.431872165838912 3.489974329495826E-5 3.4554798289399E-7 1.8639177092882875E-4 KEGG_PATHWAY hsa05230:Central carbon metabolism in cancer 25 2.28310502283105 1.6736607077884495E-7 PIK3CG, MAP2K1, PIK3R1, SLC2A2, PIK3CD, PIK3R3, ERBB2, MAPK1, MYC, MAP2K2, RET, FLT3, PIK3R5, HIF1A, MAPK3, TP53, KIT, RAF1, PIK3CB, PIK3CA, PIK3R2, KRAS, EGFR, NRAS, AKT1 842 64 6910 3.2057229809976246 4.050177229930618E-5 3.970841615519305E-7 2.163115360831469E-4 KEGG_PATHWAY hsa04120:Ubiquitin mediated proteolysis 40 3.65296803652968 1.773383949214162E-7 ANAPC7, UBE2E1, DDB1, ANAPC2, SMURF2, CBL, BTRC, CDC20, KEAP1, CUL5, SOCS1, CDC23, SMURF1, MDM2, BRCA1, SKP1, PIAS3, UBE4A, CDC27, CUL4A, TRAF6, UBE2I, ITCH, ANAPC11, WWP1, PIAS2, UBA6, CBLB, VHL, NEDD4, UBE2E3, PIAS4, SKP2, CUL4B, CBLC, NEDD4L, PIAS1, UBE4B, SOCS3, PML 842 137 6910 2.396102432512093 4.291497451391901E-5 4.1665909167321047E-7 2.2920020863459456E-4 KEGG_PATHWAY hsa05031:Amphetamine addiction 25 2.28310502283105 3.2777406398124235E-7 SIRT1, PPP1CC, ATF4, PRKCA, PPP3CC, PRKCG, PRKACG, ATF2, PPP3CA, PRKCB, CREB1, PPP3CB, PPP1CA, JUN, CALM3, CAMK2A, CAMK2G, ADCY5, PRKACA, CAMK2B, FOS, DRD1, PRKACB, CAMK2D, PPP3R1 842 66 6910 3.108579860361333 7.93181906341145E-5 7.627048677072423E-7 4.2362973052822994E-4 KEGG_PATHWAY hsa05140:Leishmaniasis 26 2.374429223744292 3.814289099999945E-7 MYD88, TNF, TLR4, MAPK12, PTPN6, JAK2, IRAK1, MAPK11, IL10, MAPK1, C3, FOS, TRAF6, MAPK13, IFNG, JAK1, ITGB1, NFKBIB, NFKBIA, MAPK3, NFKB1, JUN, IL4, RELA, MAPK14, TLR2 842 71 6910 3.0052524171155195 9.230155377648597E-5 8.791026023802218E-7 4.929754743199233E-4 KEGG_PATHWAY hsa05206:MicroRNAs in cancer 65 5.93607305936073 4.860512687371914E-7 CCND1, ITGA5, MMP9, IRS1, SOCS1, PRKCE, EZR, GRB2, MDM2, PLCG2, APC, CDKN1A, MAP2K2, PDGFB, SHC1, BCL2, CCNE1, ABL1, PRKCB, PDGFA, SOS1, TP53, TPM1, TNC, EZH2, RHOA, SHC4, VEGFA, SOS2, PLAU, E2F3, CDKN1B, APC2, DNMT1, CCND2, PRKCA, MAP2K1, CREBBP, ATM, NOTCH1, TNXB, CRKL, BRCA1, VIM, ERBB2, MYC, THBS1, CRK, UBE2I, SIRT1, EP300, PRKCG, PLCG1, NFKB1, IRS2, RAF1, TNR, PDCD4, CASP3, KRAS, RPS6KA5, EGFR, STAT3, NRAS, SPRY2 842 285 6910 1.871692294870192 1.1761751814998167E-4 1.1096638714569451E-6 6.281936136054433E-4 KEGG_PATHWAY hsa04512:ECM-receptor interaction 29 2.6484018264840183 6.515864597136172E-7 COL4A3, FN1, ITGA5, COL5A1, SPP1, COL3A1, COL4A5, RELN, COL4A1, ITGB5, ITGB8, TNXB, ITGAV, COL2A1, LAMC1, THBS1, HSPG2, COL6A2, ITGB1, COL1A1, ITGB4, LAMA1, COL1A2, TNC, LAMA5, TNR, VTN, CD36, COL11A1 842 87 6910 2.735550277117973 1.5767154314960674E-4 1.4736809198501177E-6 8.42137599421644E-4 KEGG_PATHWAY hsa04144:Endocytosis 59 5.3881278538812785 1.639394468948653E-6 TSG101, IL2RG, SRC, SMURF2, RAB11FIP3, RAB8A, CXCR4, SMAD3, CAV1, SNX3, HSPA8, MDM2, ADRB3, GIT1, SH3KBP1, RAB11FIP2, ARF1, ITCH, EPS15, WASL, ARPC5L, WWP1, CBLB, NEDD4, IGF2R, USP8, IGF1R, ARRB2, NEDD4L, RHOA, EGF, IL2RA, AP2A1, ARRB1, CLTB, CSF1R, CDC42, CBL, ERBB4, EHD2, ADRB1, CXCR2, SMURF1, PRKCI, RNF41, STAM2, RAB11B, TRAF6, RET, WAS, KIT, SMAD2, ADRB2, CCR5, CBLC, HSPA1A, EGFR, PRKCZ, PML 842 258 6910 1.8767147249995395 3.9665509824660106E-4 3.673454240682439E-6 0.0021188095164381693 KEGG_PATHWAY hsa04970:Salivary secretion 28 2.5570776255707766 1.7815560361354924E-6 PRKCA, PLCB1, PRKACG, PLCB3, ADRB1, ITPR1, ADCY2, ADCY1, PLCB4, CALM3, NOS1, ADRB3, ADCY5, PRKACA, PRKACB, VAMP2, ADCY3, ADCY7, PLCB2, ATP2B4, PRKCG, GNAQ, ADCY4, PRKCB, ATP2B1, ADCY6, ADCY8, ADRB2 842 86 6910 2.671932828812904 4.3104401861582264E-4 3.95537699204862E-6 0.0023025420394118257 KEGG_PATHWAY hsa05134:Legionellosis 21 1.9178082191780823 2.2584172605066394E-6 EEF1A1, MYD88, CASP8, NFKBIA, TNF, TLR4, NFKB1, IL6, CYCS, EEF1G, HSPA8, HSPA1A, RELA, CASP3, IL18, TLR2, C3, CASP7, VCP, ARF1, CASP9 842 54 6910 3.1914753233043016 5.463882697391842E-4 4.968511240543982E-6 0.0029188449842676434 KEGG_PATHWAY hsa04064:NF-kappa B signaling pathway 28 2.5570776255707766 2.2900423454739665E-6 CSNK2A2, MYD88, LCK, CSNK2B, TNF, TLR4, CSNK2A1, BTK, ATM, LBP, IRAK1, PLCG2, SYK, UBE2I, TRAF6, LYN, BCL2, NFKBIA, PLCG1, PIAS4, NFKB1, TRAF2, LAT, BLNK, BCL2L1, TIRAP, RELA, PLAU 842 87 6910 2.6412209572173535 5.540373467494142E-4 4.992698186434552E-6 0.002959717617345703 KEGG_PATHWAY hsa05321:Inflammatory bowel disease (IBD) 23 2.1004566210045663 3.025500593751161E-6 IFNG, IL21R, IL2RG, IL21, IL18RAP, TNF, TLR4, NFKB1, IL18R1, SMAD3, IL6, STAT6, JUN, SMAD2, IL12RB1, IL4, IL10, STAT4, RELA, IL23R, TLR2, IL18, STAT3 842 64 6910 2.949265142517815 7.319042785772778E-4 6.5372308757361E-6 0.003910228193315657 KEGG_PATHWAY hsa04726:Serotonergic synapse 32 2.922374429223744 5.04299787621116E-6 PRKCA, PLCB1, PRKACG, PLCB3, MAP2K1, KCNJ9, CACNA1A, ITPR1, PLCB4, KCNJ6, ADCY5, MAPK1, PRKACA, GNAI1, PRKACB, GNAI3, PLCB2, KCNJ3, CACNA1S, HTR2A, PRKCG, GNAQ, MAPK3, PRKCB, APP, PLA2G4A, RAF1, CACNA1B, CASP3, KRAS, PLA2G4B, NRAS 842 111 6910 2.3658813207506793 0.0012196641676197606 1.080001746078807E-5 0.0065176107778119885 KEGG_PATHWAY hsa05032:Morphine addiction 28 2.5570776255707766 5.950435685289936E-6 ADORA1, PRKCA, PRKACG, KCNJ9, CACNA1A, ADCY2, ADCY1, KCNJ6, ADCY5, PRKACA, DRD1, GNAI1, OPRM1, PRKACB, GNAI3, ADCY3, ADCY7, KCNJ3, PRKCG, ADCY4, PRKCB, ADCY8, ADCY6, GABBR2, CACNA1B, ARRB2, GABBR1, ARRB1 842 91 6910 2.5251233327242826 0.0014389734036868163 1.2631584433098197E-5 0.007690349050637479 KEGG_PATHWAY hsa05014:Amyotrophic lateral sclerosis (ALS) 19 1.7351598173515983 1.1512905457621535E-5 PPP3CC, TNF, PPP3CA, MAPK12, PPP3CB, RAC1, TP53, CYCS, BCL2L1, NOS1, MAPK11, CASP3, DAXX, MAPK14, TNFRSF1B, CASP9, MAPK13, PPP3R1, BCL2 842 50 6910 3.1185273159144895 0.0027822614754436925 2.422700355675378E-5 0.014878797112027886 KEGG_PATHWAY hsa05414:Dilated cardiomyopathy 26 2.374429223744292 1.2351365059204426E-5 ITGA5, IGF1, TNF, ACTB, PRKACG, ADRB1, ADCY1, ADCY2, ITGB8, ITGB5, ITGAV, ADCY5, ACTC1, PRKACA, PRKACB, ADCY3, ADCY7, ITGB1, CACNA1S, MYL3, ITGB4, ADCY4, ADCY8, ADCY6, TPM1, ACTG1 842 84 6910 2.5401538287524037 0.002984586044973536 2.57673301181649E-5 0.015962307409222998 KEGG_PATHWAY hsa05202:Transcriptional misregulation in cancer 41 3.744292237442922 1.6884463274912918E-5 HIST3H3, IGF1, CSF1R, CCND2, HDAC2, NCOR1, MMP9, IL3, SMAD1, IL6, FOXO1, IGFBP3, ATM, HDAC1, RARA, MDM2, CDKN1A, MYC, RXRA, FLT3, RUNX1, JUP, DDX5, NFKB1, SPI1, EWSR1, PDGFA, TP53, IGF1R, BCL2L1, PTK2, FUS, HIST1H3A, RELA, CEBPB, ZBTB16, PLAU, SP1, GZMB, CDKN1B, PML 842 168 6910 2.0028135957470874 0.004077737963931183 3.4923104774153835E-5 0.02182007477660175 KEGG_PATHWAY hsa04115:p53 signaling pathway 22 2.009132420091324 2.5662859294456665E-5 CCNB2, CCND1, IGF1, CCND2, CASP8, CCNE1, CHEK2, CDK2, CDK1, IGFBP3, TP53, ATM, CYCS, CCNB1, ATR, MDM2, CDK4, CASP3, CDKN1A, CCND3, THBS1, CASP9 842 67 6910 2.6947211685042722 0.006191246397313388 5.26299000752628E-5 0.03316280732825749 KEGG_PATHWAY hsa04530:Tight junction 35 3.1963470319634704 2.893305115293338E-5 CSNK2A2, PPP2CB, SRC, CDC42, YBX3, PRKCA, ACTB, PPP2R1A, CSNK2B, CTNNA1, EPB41, CSNK2A1, CTNNB1, ACTN2, PRKCE, ACTN1, PRKCI, ACTN4, YES1, GNAI1, TJP1, GNAI3, ACTN3, PRKCG, PRKCB, PRKCD, MPDZ, PPP2CA, RHOA, CDK4, ACTG1, KRAS, NRAS, AKT1, PRKCZ 842 137 6910 2.0965896284480814 0.006977443486354873 5.8837762038521646E-5 0.03738798091944551 KEGG_PATHWAY hsa04913:Ovarian steroidogenesis 18 1.643835616438356 3.506285667691972E-5 ADCY7, IGF1, ADCY3, PRKACG, ADCY4, ADCY2, PLA2G4A, ADCY1, ADCY6, ADCY8, IGF1R, ADCY5, LHCGR, INS, PLA2G4B, INSR, PRKACA, PRKACB 842 49 6910 3.014688060497358 0.008449461019902516 7.070883398885286E-5 0.04530740644701492 KEGG_PATHWAY hsa04350:TGF-beta signaling pathway 25 2.28310502283105 3.880670691396587E-5 PPP2CB, SMURF2, RPS6KB1, TNF, PPP2R1A, SMAD1, CREBBP, SMAD3, SMURF1, SKP1, ID1, MAPK1, MYC, THBS1, BMP4, SMAD9, IFNG, EP300, MAPK3, SMAD2, SMAD4, RHOA, PPP2CA, SP1, RPS6KB2 842 84 6910 2.4424556045696186 0.009347443780141185 7.761190786736982E-5 0.05014400323518631 KEGG_PATHWAY hsa04961:Endocrine and other factor-regulated calcium reabsorption 17 1.552511415525114 4.208248604081009E-5 PLCB2, PRKCA, PLCB1, VDR, PRKCG, GNAQ, PRKACG, PLCB3, PRKCB, BDKRB2, PLCB4, ADCY6, ESR1, AP2A1, PRKACA, PRKACB, CLTB 842 45 6910 3.100290314067036 0.010132492790391301 8.347336763481206E-5 0.05437573225490766 KEGG_PATHWAY hsa04727:GABAergic synapse 25 2.28310502283105 4.796955960514418E-5 GNAI3, ADCY7, ADCY3, CACNA1S, SRC, NSF, PRKCA, PRKCG, PRKACG, ADCY4, PRKCB, CACNA1A, ADCY2, ADCY1, ADCY6, ADCY8, GABBR2, KCNJ6, CACNA1B, GABBR1, ADCY5, PRKACA, GABARAP, GNAI1, PRKACB 842 85 6910 2.4137208327511526 0.011541788440925793 9.437694348335413E-5 0.0619803777651029 KEGG_PATHWAY hsa03013:RNA transport 40 3.65296803652968 6.916529110655978E-5 EIF3E, NCBP1, SEC13, KPNB1, SUMO3, EIF4A2, THOC1, NUP35, EIF4B, SUMO4, SAP18, NUP210, NUP155, RAN, UBE2I, EEF1A1, GEMIN6, NUP88, SRRM1, EIF4G1, ELAC2, GEMIN4, NUP98, SUMO1, DDX39B, EIF4A1, EIF4E, NXF1, NUP50, SMN2, CLNS1A, XPO1, RBM8A, EIF3D, THOC2, FMR1, XPOT, EIF2S1, EIF3C, NUP214 842 172 6910 1.9085234491520744 0.01659926767602582 1.3497943235030174E-4 0.08935560866605297 KEGG_PATHWAY hsa05216:Thyroid cancer 13 1.187214611872146 7.009414548802265E-5 TP53, CCND1, RXRA, CDH1, MAPK1, MAP2K1, MAPK3, MYC, KRAS, MAP2K2, CTNNB1, NRAS, RET 842 29 6910 3.678843476124171 0.016820309754062568 1.3569781407274384E-4 0.0905551072019728 KEGG_PATHWAY hsa04360:Axon guidance 32 2.922374429223744 9.033396178243237E-5 CDC42, PPP3CA, EFNA1, CXCR4, NRP1, PPP3CB, RGS3, RAC2, LIMK1, MAPK1, RAC3, FYN, EPHB2, GNAI1, EFNA2, EPHA8, PPP3R1, GNAI3, RASA1, PAK1, ITGB1, PPP3CC, MAPK3, ABL1, RAC1, PTK2, RHOA, NCK1, KRAS, EFNA4, NRAS, EFNA5 842 127 6910 2.067817532309649 0.021624568870034944 1.7349134703226188E-4 0.11668898391496985 KEGG_PATHWAY hsa05030:Cocaine addiction 17 1.552511415525114 1.3595525926229322E-4 GNAI3, GRM3, ATF4, PRKACG, ATF2, NFKB1, CREB1, JUN, RELA, ADCY5, GRM2, DRD2, PRKACA, GNAI1, DRD1, GPSM1, PRKACB 842 49 6910 2.8472053904697274 0.03236798085247106 2.590484056379516E-4 0.17557258381984964 KEGG_PATHWAY hsa04972:Pancreatic secretion 25 2.28310502283105 2.2433501693013672E-4 PLA2G2A, PLCB1, PRKCA, RAB8A, PLCB3, ITPR1, ADCY1, ADCY2, PLCB4, CFTR, ADCY5, RAP1B, ADCY3, ADCY7, PLCB2, ATP2B4, PRKCG, GNAQ, ADCY4, PRKCB, ATP2B1, RAC1, ADCY8, ADCY6, RHOA 842 93 6910 2.2060889331596556 0.05284750053442222 4.2409102045581903E-4 0.28955359669240455 KEGG_PATHWAY hsa04141:Protein processing in endoplasmic reticulum 38 3.4703196347031966 2.2558526325743667E-4 UBE2E1, DNAJA1, SEC13, NFE2L2, DDOST, YOD1, MAPK10, SEC31A, PDIA4, HSP90AA1, HSPA8, HSP90B1, EIF2AK1, SKP1, EIF2AK4, HSPA5, VCP, DNAJC3, SEC63, BCL2, UBQLN4, ATF4, EIF2AK2, UBE2E3, CAPN1, TRAF2, SEC24B, NPLOC4, EIF2AK3, HSPA1A, P4HB, MAPK9, SVIP, EIF2S1, UBE4B, HSPH1, SEC24A, MAPK8 842 169 6910 1.8452824354523605 0.053134091740375755 4.2314914611718546E-4 0.2911651443109453 KEGG_PATHWAY hsa05410:Hypertrophic cardiomyopathy (HCM) 22 2.009132420091324 2.916745327299316E-4 PRKAA1, PRKAG3, ITGA5, IGF1, CACNA1S, ITGB1, MYL3, TNF, ACTB, ITGB4, IL6, PRKAG2, ITGB5, ITGB8, TPM1, ITGAV, PRKAG1, PRKAA2, PRKAB2, ACTC1, ACTG1, PRKAB1 842 78 6910 2.3146963883305927 0.06816128596329729 5.428951396961867E-4 0.3763189590043403 KEGG_PATHWAY hsa05020:Prion diseases 13 1.187214611872146 3.0143253151998E-4 PRNP, MAPK1, FYN, PRKACG, MAPK3, HSPA5, LAMC1, MAP2K1, PRKACA, IL6, MAP2K2, PRKACB, EGR1 842 33 6910 3.2329230547757866 0.07035981829017246 5.567737156204622E-4 0.38888612801533107 KEGG_PATHWAY hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20 1.82648401826484 6.076547288089543E-4 ITGA5, ACTN3, DSP, CACNA1S, ITGB1, ACTB, ITGB4, CTNNA1, JUP, CTNNB1, ACTN2, ACTN1, ITGB5, ITGB8, ITGAV, GJA1, DSG2, ACTG1, ACTN4, PKP2 842 71 6910 2.3117326285503994 0.1367898797820094 0.0011137515983646873 0.7825223815547955 KEGG_PATHWAY hsa04320:Dorso-ventral axis formation 11 1.004566210045662 8.126587639606738E-4 NOTCH1, CPEB1, GRB2, MAPK1, ETS1, MAPK3, SOS2, MAP2K1, KRAS, EGFR, SOS1 842 27 6910 3.343450338699745 0.178598601043369 0.0014781799054328637 1.0452442268598205 KEGG_PATHWAY hsa03040:Spliceosome 30 2.73972602739726 0.0011173564192805917 NCBP1, PRPF31, SF3A3, SNW1, SRSF10, WBP11, SNRPF, SNRPG, THOC1, SNRPE, HSPA8, SART1, PRPF8, SRSF9, PPIL1, SNRPB2, TXNL4A, PQBP1, DDX5, DDX39B, SRSF1, SNRPD1, HNRNPC, SNRPD3, HSPA1A, RBM8A, THOC2, SNRNP70, SMNDC1, SRSF2 842 133 6910 1.8511242476738163 0.23704134212827888 0.0020170036521610646 1.4345421603892516 KEGG_PATHWAY hsa05010:Alzheimer's disease 35 3.1963470319634704 0.0017294885762151684 NDUFB5, SNCA, NDUFB10, PLCB1, TNF, PPP3CA, PLCB3, ITPR1, PPP3CB, PLCB4, CALM3, FADD, NOS1, MAPK1, NDUFB9, CASP7, CASP9, NDUFA7, PPP3R1, PLCB2, NDUFV1, CACNA1S, CASP8, NDUFA13, PPP3CC, GNAQ, MAPK3, NDUFS8, APP, CAPN1, NDUFB6, CYCS, EIF2AK3, CASP3, BACE1 842 168 6910 1.709718923198733 0.34222909705836835 0.003098143263782105 2.212367346278865 KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 44 4.018264840182648 0.002385501578457363 IL21R, KITLG, IL2RG, VEGFC, VEGFB, IL21, CSF1R, GHR, PPBP, TNF, IL3, CXCR4, IL6, CXCR2, IL6R, HGF, IL10, CCR10, IL18, CCR3, PDGFB, IFNG, FLT3, IL1RAP, IL18RAP, IL18R1, PDGFA, CCR2, PRLR, KIT, CSF1, IL12RB1, IL4, CCR5, EPOR, CCR1, IL6ST, IL23R, EGF, IL2RA, VEGFA, EGFR, TNFRSF1B, CCR9 842 230 6910 1.569967985128576 0.4389700812348377 0.004240842737608275 3.039661528597992 KEGG_PATHWAY hsa05110:Vibrio cholerae infection 15 1.36986301369863 0.0035110960032740004 ADCY3, PRKCA, PRKCG, ACTB, PLCG1, PRKACG, PRKCB, PDIA4, CFTR, PLCG2, ACTG1, PRKACA, ARF1, PRKACB, TJP1 842 53 6910 2.3226370277416755 0.5730892896228788 0.006193734849609833 4.444112664188992 KEGG_PATHWAY hsa04622:RIG-I-like receptor signaling pathway 18 1.643835616438356 0.003587825698950087 CASP8, NFKBIB, NFKBIA, TNF, IKBKE, MAPK12, NFKB1, MAPK10, TRAF2, FADD, MAPK11, RELA, MAPK9, MAPK14, TRAF6, ISG15, MAPK13, MAPK8 842 70 6910 2.1102816423481503 0.5809709905166955 0.006283185875010422 4.539164778469984 KEGG_PATHWAY hsa05034:Alcoholism 35 3.1963470319634704 0.0042101205234981644 HIST3H3, PPP1CC, HDAC2, HDAC6, HDAC3, MAP2K1, ADORA2A, PPP1CA, HDAC1, CALM3, GRB2, HDAC4, HIST1H2BJ, MAPK1, ADCY5, DRD1, GNAI1, SHC1, H2AFX, HIST1H4A, GNAI3, SHC2, ATF4, ATF2, MAPK3, SOS1, CREB1, RAF1, SHC3, SHC4, HIST1H3A, SOS2, DRD2, KRAS, NRAS 842 177 6910 1.6227840626971026 0.6397654544976638 0.007318412383662043 5.3068419122771715 KEGG_PATHWAY hsa05144:Malaria 14 1.2785388127853883 0.004643126624441638 IFNG, MYD88, HBA1, TNF, TLR4, IL6, HBB, HGF, IL10, CD36, IL18, TLR2, THBS1, SDC2 842 49 6910 2.344757380386834 0.6757541775604368 0.00801239497684314 5.837643208377075 KEGG_PATHWAY hsa05416:Viral myocarditis 15 1.36986301369863 0.0070808829470691784 CCND1, CASP8, ACTB, EIF4G1, ABL1, CAV1, RAC1, CYCS, RAC2, ACTG1, FYN, RAC3, CASP3, CD55, CASP9 842 57 6910 2.159644955619452 0.8208746201681233 0.012122163329780333 8.775090528569052 KEGG_PATHWAY hsa05016:Huntington's disease 36 3.287671232876712 0.008690115690448667 NDUFB5, HDAC2, NDUFB10, PLCB1, HIP1, CREBBP, PLCB3, ITPR1, PLCB4, HDAC1, POLR2B, NDUFB9, CASP9, NDUFA7, PLCB2, POLR2H, NDUFV1, EP300, CASP8, NDUFA13, TBP, GNAQ, TBPL1, NDUFS8, NDUFB6, POLR2D, CREB1, POLR2A, TP53, CYCS, TGM2, SOD2, CASP3, AP2A1, SP1, CLTB 842 192 6910 1.5387470308788598 0.879028339834822 0.014764559677762246 10.66760416251813 KEGG_PATHWAY hsa04710:Circadian rhythm 10 0.91324200913242 0.009419283759398316 PRKAA1, PRKAG3, PRKAA2, PRKAG1, BTRC, SKP1, PRKAB2, PRKAB1, PRKAG2, CREB1 842 31 6910 2.6473067197915867 0.8987608799393099 0.01588830222226767 11.513148087412494 KEGG_PATHWAY hsa04340:Hedgehog signaling pathway 9 0.821917808219178 0.012405508305455845 GLI3, GLI2, BTRC, PRKACG, CSNK1A1, SUFU, PRKACA, GLI1, PRKACB 842 27 6910 2.735550277117973 0.9512431684127757 0.020760022500522446 14.899512377467994 KEGG_PATHWAY hsa04070:Phosphatidylinositol signaling system 21 1.9178082191780823 0.013110435448617695 PLCB2, PIK3R5, PRKCA, PLCB1, PRKCG, PIK3CG, PLCG1, PLCB3, PRKCB, ITPR1, PLCB4, CALM3, INPP5D, PIK3R1, PIK3CD, PIK3R3, PI4KA, PIK3CB, PLCG2, PIK3CA, PIK3R2 842 98 6910 1.7585680352901256 0.9589804653265622 0.021784772971684352 15.681253479837586 KEGG_PATHWAY hsa03430:Mismatch repair 8 0.730593607305936 0.016318593617089948 RPA1, SSBP1, RFC2, MLH1, POLD2, MSH2, RFC4, PCNA 842 23 6910 2.85448724568832 0.9813456594446748 0.026903239603857543 19.156012923642752 KEGG_PATHWAY hsa04330:Notch signaling pathway 12 1.095890410958904 0.026500419951200224 HDAC1, NOTCH1, RBPJL, CTBP1, EP300, HDAC2, HES5, SNW1, KAT2A, RBPJ, CREBBP, KAT2B 842 48 6910 2.0516627078384797 0.9984959718002293 0.043251787014438214 29.328223762254623 KEGG_PATHWAY hsa04962:Vasopressin-regulated water reabsorption 11 1.004566210045662 0.03536537099428503 ADCY6, VAMP2, ADCY3, NSF, DYNLL1, PRKACG, DYNC1LI2, RAB11B, PRKACA, PRKACB, CREB1 842 44 6910 2.0516627078384797 0.9998356350102373 0.05717488222156297 37.208894972723236 KEGG_PATHWAY hsa04973:Carbohydrate digestion and absorption 10 0.91324200913242 0.06206979472179399 PIK3R1, SLC2A2, PIK3CD, PIK3R3, PIK3R5, PIK3CB, PIK3CA, PIK3CG, PIK3R2, AKT1 842 42 6910 1.953964483655695 0.999999815809864 0.09884303140286244 56.31636305674071 KEGG_PATHWAY hsa04145:Phagosome 26 2.374429223744292 0.07479669000628092 TUBB, ITGA5, TUBA1A, ACTB, TLR4, TUBB4B, MRC1, ITGB5, ITGAV, TUBA4A, NOS1, PLA2R1, THBS1, C3, CTSS, CORO1A, ITGB1, TUBA1B, DYNC1LI2, RAC1, TUBA3C, MBL2, ACTG1, CD36, TUBB2A, TLR2 842 153 6910 1.3945942589228881 0.9999999932485504 0.11787665922182988 63.38715589523984 KEGG_PATHWAY hsa04640:Hematopoietic cell lineage 16 1.461187214611872 0.08729965348480953 KITLG, ITGA5, FLT3, CSF1R, CD4, TNF, IL3, IL6, IL6R, KIT, CSF1, IL4, EPOR, CD36, IL2RA, CD55 842 85 6910 1.5447813329607378 0.9999999997491419 0.13618636721086474 69.29117019285259